NS Antibody

Size

100ug

Clone Number

Aliases

NS antibody; Non-structural protein 1 antibody; NS1 antibody; NS1A antibody

Immunogen Species

Influenza A virus (strain A/Udorn/307/1972 H3N2)

UniProt ID

P03495

Immunogen

Recombinant Influenza A virus Non-structural protein 1 protein (152-237AA)

Raised in

Rabbit

Species Reactivity

Influenza A virus

Tested Applications

ELISA

Background

Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3\'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3\' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3\' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NS

Research Areas