NRG1 Antibody

Size

100ug

Clone Number

Aliases

Acetylcholine receptor-inducing activity antibody; Acetylcholine receptor-inducing activity, chick, homolog of antibody; ARIA antibody; Breast cancer cell differentiation factor p45 antibody; GGF antibody; GGF2 antibody; glial growth factor 2 antibody; Glial growth factor antibody; Heregulin antibody; heregulin, alpha (45kD, ERBB2 p185-activator) antibody; heregulin, alpha antibody; HGL antibody; HRG antibody; HRG1 antibody; HRGA antibody; MST131 antibody; MSTP131 antibody; NDF antibody; Neu differentiation factor antibody; Neuregulin-1 antibody; nrg1 antibody; NRG1-IT2 antibody; NRG1_HUMAN antibody; Pro-NRG1 antibody; Sensory and motor neuron-derived factor antibody; SMDF antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q02297

Immunogen

Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (75-176AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NRG1

Research Areas

Neuroscience; Signal transduction