NRCAM Antibody

Size

100ug

Clone Number

Aliases

Bravo antibody; hBravo antibody; Neuronal cell adhesion molecule antibody; Neuronal surface protein Bravo antibody; Ng CAM related antibody; Ng-CAM-related antibody; NgCAM related cell adhesion molecule antibody; NgCAM-related cell adhesion molecule antibody; Nr CAM antibody; Nr-CAM antibody; Nrcam antibody; NRCAM_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92823

Immunogen

Recombinant Human Neuronal cell adhesion molecule protein (1194-1299AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

Background

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NRCAM

Research Areas

Neuroscience