NR2C2 Antibody

Size

100ul

Clone Number

Aliases

hTAK1 antibody; Nr2c2 antibody; NR2C2_HUMAN antibody; Nuclear hormone receptor TR4 antibody; Nuclear receptor subfamily 2 group C member 2 antibody; Orphan nuclear receptor TAK1 antibody; Orphan nuclear receptor TR4 antibody; TAK1 antibody; Testicular nuclear receptor 4 antibody; Testicular receptor 4 antibody; TR2R1 antibody; TR4 antibody; TR4 nuclear hormone receptor antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P49116

Immunogen

Recombinant Human Nuclear receptor subfamily 2 group C member 2 protein (240-380AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5\\\'-AGGTCA-3\\\' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NR2C2

Research Areas

Epigenetics and Nuclear Signaling