NOTCH3 Antibody

Size

100ug

Clone Number

Aliases

CADASIL antibody; CASIL antibody; NOTC3_HUMAN antibody; Notch 3 antibody; Notch 3 intracellular domain antibody; Notch homolog 3 antibody; Notch3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UM47

Immunogen

Recombinant Human Neurogenic locus notch homolog protein 3 protein (1301-1496AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NOTCH3

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cardiovascular; Stem cells