NOTCH2 Antibody

Size

100ug

Clone Number

Aliases

AGS2 antibody; hN2 antibody; Motch B antibody; N2 antibody; N2ECD antibody; N2ICD antibody; neurogenic locus notch homolog protein 2 antibody; NOTC2_HUMAN antibody; Notch 2 antibody; Notch 2 intracellular domain antibody; Notch Drosophila homolog 2 antibody; Notch homolog 2 antibody; Notch homolog 2 Drosophila antibody; Notch2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q04721

Immunogen

Recombinant Human Neurogenic locus notch homolog protein 2 protein (59-250AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NOTCH2

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Stem cells