notch1a Antibody

Size

100ug

Clone Number

Aliases

notch1a antibody; notch antibody; Neurogenic locus notch homolog protein 1 antibody; Notch 1) [Cleaved into: Notch 1 extracellular truncation antibody; NEXT); Notch 1 intracellular domain antibody; NICD)] antibody

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

UniProt ID

P46530

Immunogen

Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA)

Raised in

Rabbit

Species Reactivity

Zebrafish

Tested Applications

ELISA

Background

Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

notch1a

Research Areas

Neuroscience; Developmental biology; Stem cells