Nodal Polyclonal Antibody

Ab type

Primary antibody

Background

NODAL (nodal growth differentiation factor) encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in NODAL are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human NODAL. AA range:294-343

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

39561

synonyms

NODAL; Nodal homolog