NOD2 Antibody

Size

100ug

Clone Number

Aliases

ACUG antibody; Arthrocutaneouveal granulomatosis antibody; BLAU antibody; CARD15 antibody; Caspase recruitment domain family, member 15 antibody; Caspase recruitment domain protein 15 antibody; Caspase recruitment domain-containing protein 15 antibody; CD antibody; CLR16.3 antibody; IBD1 antibody; Inflammatory bowel disease protein 1 antibody; LRR containing protein antibody; NLR family, CARD domain containing 2 antibody; NLRC2 antibody; NOD like receptor C2 antibody; NOD2 antibody; NOD2 protein antibody; NOD2_HUMAN antibody; NOD2B antibody; nucleotide binding oligomerization domain 2 antibody; Nucleotide binding oligomerization domain containing 2 antibody; Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2 antibody; Nucleotide-binding oligomerization domain-containing protein 2 antibody; PSORAS1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9HC29

Immunogen

Recombinant Human Nucleotide-binding oligomerization domain-containing protein 2 protein (460-733AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NOD2

Research Areas

Cell biology