NMNAT1 Antibody

Size

100ul

Clone Number

Aliases

EC 2.7.7.1 antibody; LCA9 antibody; Leber's congenital amaurosis 9 antibody; NaMN adenylyltransferase 1 antibody; nicotinamide nucleotide adenylyltransferase 1 antibody; Nicotinamide-nucleotide adenylyltransferase 1 antibody; Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 antibody; nicotinate nucleotide adenylyltransferase 1 antibody; Nicotinate-nucleotide adenylyltransferase 1 antibody; NMN adenylyltransferase 1 antibody; NMN/NaMN adenylyltransferase 1 antibody; NMNA1_HUMAN antibody; Nmnat 1 antibody; Nmnat1 antibody; OTTHUMP00000001731 antibody; OTTHUMP00000001732 antibody; OTTHUMP00000035892 antibody; PNAT 1 antibody; PNAT1 antibody; pyridine nucleotide adenylyltransferase 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9HAN9

Immunogen

Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 protein (1-279AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following mechanical or toxic insults.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NMNAT1

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Metabolism; Signal transduction