NME4 Antibody

Size

100ul

Clone Number

Aliases

metastatic inhibition factor NM23H4 antibody; mitochondrial antibody; NDK antibody; NDKM_HUMAN antibody; NDP kinase antibody; NDP kinase D antibody; NDP kinase, mitochondrial antibody; NDPK D antibody; NDPKD antibody; nm23 H4 antibody; nm23-H4 antibody; NM23D antibody; NM23H4 antibody; Nm23M4 antibody; NME/NM23 nucleoside diphosphate kinase 4 antibody; NME4 antibody; Non metastatic cells 4 protein expressed in antibody; Non metastatic protein 23, homolog 4 antibody; Nucleoside diphosphate kinase D antibody; Nucleoside diphosphate kinase, mitochondrial antibody; Nucleoside diphosphate kinase, mitochondrial antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O00746

Immunogen

Recombinant Human Nucleoside diphosphate kinase, mitochondrial protein (1-187AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NME4

Research Areas

Neuroscience; Cancer; Metabolism; Signal transduction