NMDA Epsilon 1/2(Phospho Tyr1246/1252) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent| and are involved in long-term potentiation| an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions| and activation results in a calcium influx into post-synaptic cells| which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human NMDAR2A/B around the phosphorylation site of Tyr1246/1252. AA range:1216-1265

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

165283;166367

synonyms

Glutamate [NMDA] receptor subunit epsilon-1/2; GRIN2A; NMDAR2A; Glutamate [NMDA; receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA; receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; N