NLRP6 Antibody, FITC conjugated

Size

100ug

Clone Number

Aliases

Angiotensin II/vasopressin receptor antibody; AVR antibody; CLR11.4 antibody; NACHT, leucine rich repeat and PYD containing 6 antibody; NACHT, LRR and PYD containing protein 6 antibody; NACHT, LRR and PYD domains-containing protein 6 antibody; NAVR antibody; NAVR/AVR antibody; NLR family, pyrin domain containing 6 antibody; Nlrp6 antibody; NLRP6_HUMAN antibody; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 antibody; PAN3 antibody; PYPAF5 antibody; PYRIN containing APAF1 like protein 5 antibody; PYRIN-containing APAF1-like protein 5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P59044

Immunogen

Recombinant Human NACHT, LRR and PYD domains-containing protein 6 protein (154-306AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

Background

As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

FITC

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NLRP6

Research Areas

Cell biology; Immunology; Signal transduction