NLRP2 Antibody

Size

100ul

Clone Number

Aliases

CLR19.9 antibody; FLJ20510 antibody; Leucine rich repeat and PYD containing protein 2 antibody; LRR and PYD domains-containing protein 2 antibody; NACHT antibody; NACHT domain antibody; NACHT leucine rich repeat and PYD containing 2 antibody; NACHT LRR and PYD domains containing protein 2 antibody; NALP2 antibody; NALP2_HUMAN antibody; NBS1 antibody; NLR family pyrin domain containing 2 antibody; NLRP2 antibody; Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody; Nucleotide-binding site protein 1 antibody; PAN1 antibody; PYPAF2 antibody; PYRIN containing APAF1 like protein2 antibody; PYRIN domain and NACHT domain-containing protein 1 antibody; PYRIN-containing APAF1-like protein 2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NX02

Immunogen

Recombinant Human NACHT, LRR and PYD domains-containing protein 2 protein (1-220AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NLRP2

Research Areas

Cell biology