Nibrin Polyclonal Antibody

Ab type

Primary antibody

Background

Mutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human NBN. AA range:431-480

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

84959

synonyms

NBN; NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1