NHLRC1 Antibody

Size

100ul

Clone Number

Aliases

bA204B7.2 antibody; E3 ubiquitin-protein ligase NHLRC1 antibody; EPM2A antibody; EPM2B antibody; EPM2B gene antibody; Malin antibody; MGC119262 antibody; MGC119264 antibody; MGC119265 antibody; NHL repeat containing 1 antibody; NHL repeat containing E3 ubiquitin protein ligase 1 antibody; NHL repeat containing protein 1 antibody; NHL repeat-containing protein 1 antibody; NHL repeat-containing protein 1 gene antibody; NHLC1_HUMAN antibody; NHLRC 1 antibody; Nhlrc1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q6VVB1

Immunogen

Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (1-280AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NHLRC1

Research Areas

Cell biology