NFE2 Polyclonal Antibody

Ab type

Primary antibody

Background

Required for activity at the locus control region (LCR) upstream of the globin gene complexes. Requires p18 NF-E2 for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production: globin synthesis| heme synthesis| and the procurement of iron.|Belongs to the bZIP family.|Belongs to the bZIP family. CNC subfamily.|Contains 1 bZIP domain.|subunit:Interacts with MLL2; leading to activate transcription of the beta-globin locus (By similarity). Heterodimer of p45 NF-E2 and p18 NF-E2. Forms high affinity heterodimer with MAFG; the interaction promotes erythropoiesis.|tissue specificity:Expressed in hematopoietic cells and also in colon and testis.|

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from part region of human protein

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

Transcription factor NF-E2 45 kDa subunit ;Leucine zipper protein NF-E2;Nuclear factor; erythroid-derived 2 45 kDa subunit;p45 NF-E2