NF-E4 Polyclonal Antibody

Ab type

Primary antibody

Background

The erythroid-specific protein encoded by this gene| and the ubiquitous transcription factor CP2| form the stage selector protein (SSP) complex| which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon| and a downstream AUG codon| results in two isoforms. While the long isoform (22 kDa) acts as an activator| the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand.

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human NF-E4

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

NF-E4; Transcription factor NF-E4