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SKU:PAA005Mu01

Polyclonal Antibody to Angiotensin II (AngII)

Polyclonal Antibody to Angiotensin II (AngII)

Regular price $324.00 USD
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UOM
Concentration
Organism species

Western blotting: 0.5-2µg/mL;
;Immunohistochemistry: 5-20µg/mL;
;Immunocytochemistry: 5-20µg/mL;
;Optimal working dilutions must be determined by end user.

Product No.

PAA005Mu01

Organism Species

Mus musculus (Mouse).

Source

Polyclonal antibody preparation

Host

Rabbit

Potency

n/a

Ig Type

IgG

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Label

None

Immunogen

n/a

Buffer Formulation

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Traits

Liquid

Concentration

500µg/mL

Organism Species More

n/a

Applications

ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).

If the antibody is used in flow cytometry, please check FCM antibodies.

UOM

20µl 100µl 200µl 1ml 10ml

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against AngII. It has been selected for its ability to recognize AngII in immunohistochemical staining and western blotting.

USAGE

Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Magazine

Citations

Nature Medicine

Angiotensin-Converting Enzyme 2 Overexpression Remarkably Ameliorated Glomerular Injury in a Rat Model of Diabetic Nephropathy: A Comparison with ACE Inhibition MolMed: 10_11_liu

The European Journal of Clinical Investigation

Mesangial medium with IgA1 from IgA nephropathy inhibits nephrin expression in mouse podocytes Wiley: source

Immunopharmacology and Inflammation

Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid ScienceDirect: S0188440910001049

Nephrology

Effect of aggregated immunoglobulin A1 from immunoglobulin A nephropathy patients on nephrin expression in podocytes Wiley: source

PLoS One

Angiotensin II and Angiotensin-(1-7) in Paraventricular Nucleus Modulate Cardiac Sympathetic Afferent Reflex in Renovascular Hypertensive Rats PubMed: PMC3527547

BioMed Research International

Heterogeneous Downregulation of Angiotensin II AT1-A and AT1-B Receptors in Arterioles in STZ-Induced Diabetic Rat Kidneys Hindawi: 947506

34

Biglcan is beneficial in angiotensin II induced heart failure by preventing cardiac inflammation and remodeling improving LV function and mortality by preventing transdifferentiation of myofibroblasts Oxfordjournals: Source

Pflügers Archiv-European Journal of Physiology

SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats Pubmed: 23114721

Eur J Pharmacol.

Angiotensin II and vasopressin are involved in the defense system against anaphylactic hypotension in anesthetized rats Pubmed:24650734

J Mol Cell Cardiol.

Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction Pubmed:25871829

Mol Med Rep.

High glucose induces activation of the local renin?angiotensin system in glomerular endothelial cells Pubmed:24337709

Mol Med Rep.

Angiotensin II promotes the progression of human gastric cancer Pubmed:24424956

PLOS ONE

Intermedin in the Paraventricular Nucleus Attenuates Cardiac Sympathetic Afferent Reflex in Chronic Heart Failure Rats Pubmed:24709972

Journal of Vascular Surgery

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice Pubmed:25037606

Biochim Biophys Acta.

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis Pubmed:25092171

Acta Physiologica

Superoxide anions in the paraventricular nucleus mediate cardiac sympathetic afferent reflex in insulin resistance rats Pubmed:25307720

Neuroscience Letters

Administration of exogenous 1,25(OH)2D3 normalizes overactivation of the central renin-angiotensin system in 1α(OH)ase knockout mice Pubmed:25576706

34

A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling PubMed: 26069213

Life Sci

Cardioprotective effects of baicalein on heart failure via modulation of Ca2 PubMed: 26706290

Physiological Research

Renal Sympathetic Denervation Improves Cardiac Dysfunction PubMed: 25804096

Nutrition

Effects of Rubus occidentalis extract on blood pressure in subjects with prehypertension: randomized, double-blinded, placebo controlled clinical trial PubMed: 26740254

J Am Soc Hypertens

Angiotensin-(1–7) enhances the effects of angiotensin II on the cardiac sympathetic afferent reflex and sympathetic activity in rostral ventrolateral medulla in renovascular hypertensive rats PubMed: 26428223

PLoS One.

Up ReCavia (Guinea pig )lation of cystathione γ lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol–Caffeine Induced Left Ventricular Hypertrophy in Wistar Kyoto Rats Pubmed:26963622

Nutrition

Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial Pubmed:26740254

Journal of Atherosclerosis and Thrombosis

Involvement of Angiotensin II Type 1 and 2 Receptors in Gelatinase ReCavia (Guinea pig )lation in Human Carotid Atheroma in vitro Pubmed:26947595

Mol Neurobiol

A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats Pubmed:26867655

Life Sci

Cardioprotective effects of baicalein on heart failure via modulation of Ca(2+) handling proteins in vivo and in vitro Pubmed:26706290

PLoS One.

Paradoxical Sleep Deprivation Causes Cardiac Dysfunction and the Impairment Is Attenuated by Resistance Training. pubmed:27880816

Oxidative Medicine and Cellular Longevity

Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic db/db Mice pubmed:27698952

Journal of the Renin-Angiotensin-Aldosterone System

Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin converting enzyme-2/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury 1470320316661871.abstract

Microvascular Research

Pleiotropic effects of survivin in vascular endothelial cells. pubmed:27373518

PLOS ONE

Reduced Expression of the Extracellular Calcium-Sensing Receptor (CaSR) Is Associated withActivation of the Renin-Angiotensin System (RAS) to Promote Vascular Remodeling in the Pathogenesis of Essential Hypertension. pubmed:27391973

journal of pharmacological sciences

β-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibitionof renal fibroblast activation and fibrosis. pubmed:28433566

Experimental Animals

Ginsenoside Rb1 improves cardiac function and remodeling in heart failure. pubmed:28367863

Oncotarget

Effects of renal denervation on monocrotaline induced pulmonary remodeling pubmed:28187460

The American Journal of Pathology

The Renin-Angiotensin System Regulates Neurodegeneration in a Mouse Model of Optic Neuritis pubmed:28919108

PLoS One

Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy pubmed:29240788

Frontiers in Physiology

Hydrogen Sulfide Attenuates Atherosclerosis in a Partially Ligated Carotid Artery Mouse model via Regulating Angiotensin Converting Enzyme 2 Expression pubmed:29066981

Neurotherapeutics

Brain Renin–Angiotensin System Blockade Attenuates Methamphetamine-Induced Hyperlocomotion and Neurotoxicity Pubmed:29464572

International Journal of Cardiology

ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in … Pubmed:29506687

Neuroscience

Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats Pubmed:29684507

American Journal of Physiology-Renal Physiology

Role of (Pro) Renin Receptor in Albumin Overload-Induced Nephropathy in Rats Pubmed:29846109

Journal of the American Society of Hypertension

Mesenchymal stem cell–derived microvesicles alleviate pulmonary arterial hypertension by regulating renin-angiotensin system Pubmed:29752040

Evidence-based Complementary and Alternative Medicine 

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects Pubmed:29977313

Brazilian Journal of Medical and Biological Research

Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection Pubmed:29590257

American Journal of Physiology-Heart and Circulatory Physiology

Sex Differences in the Central and Peripheral Manifestations of Ischemia-induced Heart Failure in Rats Pubmed: 30289294

Toxicology Mechanisms and Methods

Long-term exposure to crotonaldehyde causes heart and kidney dysfunction through induction of inflammatory and oxidative damage in male Wistar rats Pubmed: 30426860

Journal of Clinical and Aesthetic Dermatology

Detection of Angiotensin II and AT1 Receptor Concentrations in Keloid and Hypertrophic Scar.

International Journal of Ophthalmology

Serum microRNA-221 as a biomarker for diabetic retinopathy in patients associated with type 2 diabetes Pubmed: 30588418

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

ACE Gene Plays a Key Role in Reducing Blood Pressure in The Hyperintensive Elderly After Resistance Training Pubmed: 30908459

The American Journal of the Medical Sciences

T lymphocyte-based renin angiotensin system in obesity

Journal of Alzheimers Disease

Cerebrospinal Fluid Changes in the Renin-Angiotensin System in Alzheimer's Disease Pubmed: 31594235

Andrologia

Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status Pubmed: 31989676

Molecular Medicine Reports

BPA disrupts 17‑estradiol‑mediated hepatic protection against ischemia/reperfusion injury in rat liver by upregulating the Ang II/AT1R signaling pathway Pubmed: 32319667

MOLECULAR MEDICINE REPORTS

The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFβ by suppressing the expression of the TGFβ receptor ALK5 in aorta … Pubmed: 32319652

Cell Mol Neurobiol

Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors Pubmed: 33201417

biochemistry biophysical reports

Effect of repetitive potassium iodide on thyroid and cardiovascular functions in elderly rats Pubmed: 33024842

bioscience reports

Angiotensin II enhances the proliferation of Natural Killer/T-cell lymphoma cells via activating PI3K/Akt signaling pathway Pubmed: 32969473

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

A (pro) renin receptor decoy peptide PRO20 protects against adriamycin-induced nephropathy by targeting intrarenal renin-angiotensin system Pubmed: 32865014

Acta Endocrinologica-Bucharest

THE ROLE OF HIGH FOLLICULAR LEVELS OF ANGIOTENSIN II AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN ANTICIPATING THE … Pubmed: 32685035

JOURNAL OF PROTEOME RESEARCH

Proteomics and informatics for understanding phases and identifying biomarkers in COVID-19 disease Pubmed: 32657586

Scientific Reports

Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in rats Pubmed: 32616735

BIOMEDICINE & PHARMACOTHERAPY

Semen Brassicae reduces thoracic aortic remodeling, inflammation, and oxidative damage in spontaneously hypertensive rats Pubmed: 32570115

CLINICAL AND EXPERIMENTAL HYPERTENSION

Hyperinsulinemia rather than insulin resistance itself induces blood pressure elevation in high fat diet-fed rats Pubmed: 32349626

Evidence-Based Complementary and Alternative Medicine

Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats Pubmed: 33133215

Oxidative Medicine and Cellular Longevity

Sinapic Acid Attenuates Cardiovascular Disorders in Rats by Modulating Reactive Oxygen Species and Angiotensin Receptor Expression Pubmed: 32765804

Nutrition

Gut Dysbiosis Contribute to High Fructose Induced Salt Sensitive Hypertension In Sprague-Dawley Rats


Dikkat Eksikliği Hiperaktivite Bozukluğu Tanısı Olan Anjiyotensin I, II, III, Alamandin peptid, Anjiyotensin Dönüştürücü Enzim (ACE), NADPH Oksidaz Enzim Serum …

Physiol Behav

Low-load resistance training with blood flow restriction prevent renal function decline: The role of the redox balance, angiotensin 1-7 and vasopressin 33340514

ACTA PHARMACOLOGICA SINICA

The vascular endothelial growth factor trap aflibercept induces vascular dysfunction and hypertension via attenuation of eNOS/NO signaling in mice 33303990

Int J Hypertens

The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models 33884205

Physiol Rep

(Pro) renin receptor antagonist PRO20 attenuates nephrectomy©\induced nephropathy in rats via inhibition of intrarenal RAS and Wnt/¦Â©\catenin signaling 34057312

Redox Biology

Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney 33360353

Basic and Clinical Neuroscience

Paeonol Protects Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease 33995926

researchsquare

Ang-(1-7) Protects Skeletal Muscle Function in Aged Mice

Molecular Medicine Reports

Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats 34278476

BMC Musculoskeletal Disorders

Ang-(1–7) protects skeletal muscle function in aged mice 34548056

J Am Heart Assoc

Maternal Angiotensin II–Induced Hypertension Sensitizes Postweaning High‐Fat Diet–Elicited Hypertensive Response Through Increased Brain Reactivity in Rat … 34482712

Biomed Pharmacother

Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti … 34736077

J Am Heart Assoc

Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension‐Induced Hypertensive Response Sensitization Elicited by Postweaning … Pubmed:35014859

J Gerontol A Biol Sci Med Sci

Dysregulation of ACE-1 in normal aging and the early stages of Alzheimer's disease Pubmed:35396835

Biomedicine & Pharmacotherapy

Corynoline protects ang II-induced hypertensive heart failure by increasing PPARα and Inhibiting NF-κB pathway Pubmed:35658238


Catalog No.

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Applications (RESEARCH USE ONLY!)

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