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SKU:PAA946Ra01

Polyclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)

Polyclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)

Regular price $342.00 USD
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UOM
Concentration
Organism species

Immunohistochemistry: 5-20µg/mL;1:10-40
Immunocytochemistry: 5-20µg/mL;1:10-40
Optimal working dilutions must be determined by end user.

Product No.

PAA946Ra01

Organism Species

Rattus norvegicus (Rat).

Source

Polyclonal antibody preparation

Host

Rabbit

Potency

n/a

Ig Type

IgG

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Label

None

Immunogen

CPA946Ra21-OVA Conjugated Amyloid Beta Peptide 1-42 (Ab1-42)

Buffer Formulation

PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Traits

Liquid

Concentration

0.2mg/ml

Organism Species More

n/a

Applications

WB; IHC; ICC; IP.

If the antibody is used in flow cytometry, please check FCM antibodies.

UOM

20µl 100µl 200µl 1ml 10ml

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against Ab1-42. It has been selected for its ability to recognize Ab1-42 in immunohistochemical staining and western blotting.

USAGE

Immunohistochemistry: 5-20µg/mL;1:10-40
Immunocytochemistry: 5-20µg/mL;1:10-40
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Magazine

Citations

Neuropsychopharmacology

Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease Pubmed: 23493042

Neuropharmacology and analgesia

The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1–42 seeding and short-term memory deficits in the Aβ25–35 mouse model of Alzheimer's disease Pubmed: 23123349

世界科技研究与发展(World Sci-tech R & D)

慢病毒介导的CBS基因过表达对原代皮质神经元 Globesci:Source

南方医科大学学报

外源性硫化氢对高糖条件下原代神经元β淀粉样蛋白的影响 J-Smu:Source

Neurochemical research

Effects of Aluminium on β-Amyloid (1–42) and Secretases (APP-Cleaving Enzymes) in Rat Brain Pubmed:24792732

Indian J Biochem Biophys.

Amyloid ? lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity Pubmed:25296496

Cell Mol Neurobiol

Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells PubMed: 25809614

Neuropsychiatr Dis Treat

Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex PubMed: 26316755

Neurochem Int

Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS2 transgenic model of Alzheimer's disease PubMed: 25882166

Journal of Alzheimer’s Parkinsonism & Dementia

The Potential Effect of Epigallocatechin-3-Gallate alone or in Combination with Vitamin E and Selenium on Alzheimer's Disease Induced by Aluminum in Rats open-access:

世界科技研究与发展

芝麻素对高糖条件下PC12细胞Aβ和BACE-1表达的影响 article:10299

Am J Alzheimers Dis Other Demen.

Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimer's Disease Pubmed:26993489

Світ медицини та біології

ОСОБЕННОСТИ ПРОЦЕССОВ ФОРМИРОВАНИЯ ПОКАЗАТЕЛЕЙ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ И ХАРАКТЕРИСТИКИ ВНИМАНИЯ СТУДЕНТОВ SMB-2016-03-062.pdf

世界科技研究与发展

芝麻素对高糖条件下PC12 细胞Aß 和BACE 1 表达的影响 QK:92621A

Archives of Pharmacal Research

Geniposide attenuates the level of Aβ1–42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice pubmed:28160136

Food Funct.

Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease. pubmed:28232989

Scientific Reports

Norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer’s disease articles:srep41041.ris

Journal of Medicinal Food

Cerebrosides from Sea Cucumber Protect Against Oxidative Stress in SAMP8 Mice and PC12 Cells pubmed:28406733

Journal of Nutritional Biochemistry

Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet Pubmed:29986309

Biochemical Pharmacology

Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve and Aβ-treated female rats Pubmed:30028991

Journal of Affective Disorders

Sub-chronic celecoxib prevents soluble beta amyloid-induced depressive-like behaviour in rats Pubmed:29879605

Biomedicine & Pharmacotherapy

Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain modulating apoptotic mediator … Pubmed:29579708

Journal of Agricultural and Food Chemistry

Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice Pubmed:29695154

Neurotoxicology

Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats Pubmed:29522778

Biochemical and Biophysical Research Communications

CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease Pubmed:29777699

Oncotarget

Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse … Pubmed:29731975

Experimental and Therapeutic Medicine

Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation Doi: 10.3892/etm.2018.6860


非编码RNA miR-137 调控tau 蛋白磷酸化和L 型钙离子通道CACNA1C 参与阿尔茨海默病的发生

台湾农业研究

(台灣農業研究67 (4): 355-364) 香菇柄水萃物改善糖尿病降低阿茲海默氏症罹病風險初探


The Efficacy of Sauropus androgynus Leaves Extract To Improve Cognitive Function in Wistar Rats Induced Alzheimer's

Neurotoxicity Research

Effect of Aluminum-Maltolate on the Content of Aβ Protein and the Expression of ApoER2, VLDLRs, and LRP1 in PC12-ApoE4 Cells Pubmed: 30649678

Neurochemical Research

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation Pubmed: 30756214

Molecular and Cellular Biochemistry

Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β level

PLoS One

Obstructive sleep apnea may increase the risk of Alzheimer's disease Pubmed: 31487291

Metabolic Brain Disease

Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and … Pubmed: 31728888

博士论文

Neurobiological determinants of depressive-like symptoms in rodents

Pharmacognosy Magazine

Mahanimbine-induced neuroprotection via cholinergic system and attenuated amyloidogenesis as well as neuroinflammation in lipopolysaccharides-induced …

biosciences biotechnology research asia

Dietary Malted Barley Grain Improved Structure and Function of Spinal Cord of Mother Rats fed on a high cholesterol diet.

Neurochem Res

Ex Vivo Investigation of Bexarotene and Nicotinamide Function as a Protect?ve Agent on Rat Synaptosomes Treated with A¦Â (1-42) 33428094

Food Funct

Comparative study on the effects of phosphatidylserine rich in DHA and EPA on A¦Â-intervened Alzheimer's disease using cell models 33876786

Int J Neurosci

Protective effects of repetitive transcranial magnetic stimulation against 6-OHDA-induced Parkinson's symptoms in a mice model: the key role of miR-409-3p/PDHB ¡­ 34078216

Brain Res Bul

Immunization with A¦Â3-10-KLH vaccine improves cognitive function and ameliorates mitochondrial dysfunction and reduces Alzheimer's disease-like pathology in Tg ¡­ 34044034

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The effect of a 6-month Ketogenic Medium-Chain Triglyceride Supplement on Plasma Cardiometabolic and Inflammatory Markers in Mild Cognitive?¡­ 33906081

Crystals

Potential Therapeutic Effects of New Ruthenium (III) Complex with Quercetin: Characterization, Structure, Gene Regulation, and Antitumor and Anti-Inflammatory Studies (RuIII/Q Novel Complex Is a Potent Immunoprotective Agent)

Neurosci Lett

GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal 34695452

Arch Gerontol Geriatr

The influence of vinpocetine alone or in combination with Epigallocatechin-3-gallate, Coenzyme COQ10, Vitamin E and Selenium as a potential neuroprotective … 34706318

Metab Brain Dis

Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1–42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal … Pubmed:35312928

Medicinal Chemistry Research

New Thienopyridine Scaffold as An Antidementia Lead: In Silico Study and Biological Screening


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