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SKU:PAA946Ra01
Polyclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)
Polyclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)
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Immunohistochemistry: 5-20µg/mL;1:10-40
Immunocytochemistry: 5-20µg/mL;1:10-40
Optimal working dilutions must be determined by end user.
Product No.
PAA946Ra01
Organism Species
Rattus norvegicus (Rat).
Source
Polyclonal antibody preparation
Host
Rabbit
Potency
n/a
Ig Type
IgG
Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Label
None
Immunogen
CPA946Ra21-OVA Conjugated Amyloid Beta Peptide 1-42 (Ab1-42)
Buffer Formulation
PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Traits
Liquid
Concentration
0.2mg/ml
Organism Species More
n/a
Applications
WB; IHC; ICC; IP.
If the antibody is used in flow cytometry, please check FCM antibodies.
UOM
20µl 100µl 200µl 1ml 10ml
SPECIFITY
The antibody is a rabbit polyclonal antibody raised against Ab1-42. It has been selected for its ability to recognize Ab1-42 in immunohistochemical staining and western blotting.
USAGE
Immunohistochemistry: 5-20µg/mL;1:10-40
Immunocytochemistry: 5-20µg/mL;1:10-40
Optimal working dilutions must be determined by end user.
STORAGE
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
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Magazine |
Citations |
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Neuropsychopharmacology |
Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease Pubmed: 23493042 |
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Neuropharmacology and analgesia |
The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1–42 seeding and short-term memory deficits in the Aβ25–35 mouse model of Alzheimer's disease Pubmed: 23123349 |
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世界科技研究与发展(World Sci-tech R & D) |
慢病毒介导的CBS基因过表达对原代皮质神经元 Globesci:Source |
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南方医科大学学报 |
外源性硫化氢对高糖条件下原代神经元β淀粉样蛋白的影响 J-Smu:Source |
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Neurochemical research |
Effects of Aluminium on β-Amyloid (1–42) and Secretases (APP-Cleaving Enzymes) in Rat Brain Pubmed:24792732 |
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Indian J Biochem Biophys. |
Amyloid ? lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity Pubmed:25296496 |
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Cell Mol Neurobiol |
Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells PubMed: 25809614 |
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Neuropsychiatr Dis Treat |
Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex PubMed: 26316755 |
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Neurochem Int |
Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS2 transgenic model of Alzheimer's disease PubMed: 25882166 |
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Journal of Alzheimer’s Parkinsonism & Dementia |
The Potential Effect of Epigallocatechin-3-Gallate alone or in Combination with Vitamin E and Selenium on Alzheimer's Disease Induced by Aluminum in Rats open-access: |
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世界科技研究与发展 |
芝麻素对高糖条件下PC12细胞Aβ和BACE-1表达的影响 article:10299 |
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Am J Alzheimers Dis Other Demen. |
Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimer's Disease Pubmed:26993489 |
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Світ медицини та біології |
ОСОБЕННОСТИ ПРОЦЕССОВ ФОРМИРОВАНИЯ ПОКАЗАТЕЛЕЙ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ И ХАРАКТЕРИСТИКИ ВНИМАНИЯ СТУДЕНТОВ SMB-2016-03-062.pdf |
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世界科技研究与发展 |
芝麻素对高糖条件下PC12 细胞Aß 和BACE 1 表达的影响 QK:92621A |
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Archives of Pharmacal Research |
Geniposide attenuates the level of Aβ1–42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice pubmed:28160136 |
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Food Funct. |
Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease. pubmed:28232989 |
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Scientific Reports |
Norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer’s disease articles:srep41041.ris |
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Journal of Medicinal Food |
Cerebrosides from Sea Cucumber Protect Against Oxidative Stress in SAMP8 Mice and PC12 Cells pubmed:28406733 |
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Journal of Nutritional Biochemistry |
Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet Pubmed:29986309 |
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Biochemical Pharmacology |
Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve and Aβ-treated female rats Pubmed:30028991 |
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Journal of Affective Disorders |
Sub-chronic celecoxib prevents soluble beta amyloid-induced depressive-like behaviour in rats Pubmed:29879605 |
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Biomedicine & Pharmacotherapy |
Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain modulating apoptotic mediator … Pubmed:29579708 |
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Journal of Agricultural and Food Chemistry |
Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice Pubmed:29695154 |
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Neurotoxicology |
Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats Pubmed:29522778 |
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Biochemical and Biophysical Research Communications |
CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease Pubmed:29777699 |
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Oncotarget |
Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse … Pubmed:29731975 |
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Experimental and Therapeutic Medicine |
Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation Doi: 10.3892/etm.2018.6860 |
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非编码RNA miR-137 调控tau 蛋白磷酸化和L 型钙离子通道CACNA1C 参与阿尔茨海默病的发生 |
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台湾农业研究 |
(台灣農業研究67 (4): 355-364) 香菇柄水萃物改善糖尿病降低阿茲海默氏症罹病風險初探 |
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The Efficacy of Sauropus androgynus Leaves Extract To Improve Cognitive Function in Wistar Rats Induced Alzheimer's |
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Neurotoxicity Research |
Effect of Aluminum-Maltolate on the Content of Aβ Protein and the Expression of ApoER2, VLDLRs, and LRP1 in PC12-ApoE4 Cells Pubmed: 30649678 |
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Neurochemical Research |
Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation Pubmed: 30756214 |
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Molecular and Cellular Biochemistry |
Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β level |
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PLoS One |
Obstructive sleep apnea may increase the risk of Alzheimer's disease Pubmed: 31487291 |
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Metabolic Brain Disease |
Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and … Pubmed: 31728888 |
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博士论文 |
Neurobiological determinants of depressive-like symptoms in rodents |
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Pharmacognosy Magazine |
Mahanimbine-induced neuroprotection via cholinergic system and attenuated amyloidogenesis as well as neuroinflammation in lipopolysaccharides-induced … |
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biosciences biotechnology research asia |
Dietary Malted Barley Grain Improved Structure and Function of Spinal Cord of Mother Rats fed on a high cholesterol diet. |
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Neurochem Res |
Ex Vivo Investigation of Bexarotene and Nicotinamide Function as a Protect?ve Agent on Rat Synaptosomes Treated with A¦Â (1-42) 33428094 |
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Food Funct |
Comparative study on the effects of phosphatidylserine rich in DHA and EPA on A¦Â-intervened Alzheimer's disease using cell models 33876786 |
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Int J Neurosci |
Protective effects of repetitive transcranial magnetic stimulation against 6-OHDA-induced Parkinson's symptoms in a mice model: the key role of miR-409-3p/PDHB ¡ 34078216 |
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Brain Res Bul |
Immunization with A¦Â3-10-KLH vaccine improves cognitive function and ameliorates mitochondrial dysfunction and reduces Alzheimer's disease-like pathology in Tg ¡ 34044034 |
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PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS |
The effect of a 6-month Ketogenic Medium-Chain Triglyceride Supplement on Plasma Cardiometabolic and Inflammatory Markers in Mild Cognitive?¡ 33906081 |
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Crystals |
Potential Therapeutic Effects of New Ruthenium (III) Complex with Quercetin: Characterization, Structure, Gene Regulation, and Antitumor and Anti-Inflammatory Studies (RuIII/Q Novel Complex Is a Potent Immunoprotective Agent) |
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Neurosci Lett |
GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal 34695452 |
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Arch Gerontol Geriatr |
The influence of vinpocetine alone or in combination with Epigallocatechin-3-gallate, Coenzyme COQ10, Vitamin E and Selenium as a potential neuroprotective … 34706318 |
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Metab Brain Dis |
Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1–42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal … Pubmed:35312928 |
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Medicinal Chemistry Research |
New Thienopyridine Scaffold as An Antidementia Lead: In Silico Study and Biological Screening |
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