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SKU:PAH337Mu01

Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a)

Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a)

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UOM
Concentration
Organism species

Western blotting: 0.5-2µg/mL;
;Immunohistochemistry: 5-20µg/mL;
;Immunocytochemistry: 5-20µg/mL;
;Optimal working dilutions must be determined by end user.

Product No.

PAH337Mu01

Organism Species

Mus musculus (Mouse).

Source

Polyclonal antibody preparation

Host

Rabbit

Potency

n/a

Ig Type

IgG

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Label

None

Immunogen

RPH337Mu01-Recombinant Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a)

Buffer Formulation

PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Traits

Liquid

Concentration

0.5mg/ml

Organism Species More

Homo sapiens (Human), Rattus norvegicus (Rat)

Applications

WB; IHC; ICC; IP.

If the antibody is used in flow cytometry, please check FCM antibodies.

UOM

20µl 100µl 200µl 1ml 10ml

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against PPARgC1a. It has been selected for its ability to recognize PPARgC1a in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.01-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Magazine

Citations

Coronary Artery Disease

Impaired myocardium energetics associated with the risk for new-onset atrial fibrillation after isolated coronary artery bypass graft surgery Pubmed: 24463787

Molecular and cellular biochemistry

Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension Pubmed: 23099843

Diabetes.

Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway Pubmed:25249574

Psychoneuroendocrinology

Maternal stress predicts altered biogenesis and the profile of mitochondrial proteins in the frontal cortex and hippocampus of adult offspring rats PubMed: 26143539

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

The level of circulating PGC1α in cardiovascular diseases Article: 10.1134

Neuroscience Letters

Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis pubmed:28483651

The American Journal of the Medical Sciences

Serum peroxisome proliferator-activated receptor gamma coactivator-1α related to myocardial energy expenditure in patients with chronic heart failure Doi: 10.1016/j.amjms.2018.12.002

Brain Research

The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia Pubmed: 31866362

Food & Function

Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise Pubmed: 32797125


Brown and beige adipose tissue regulate systemic metabolism to resist diet-induced obesity through metabolite signals in an inter-organ signaling axis

CLINICAL NUTRITION

Long lasting protective EFFECTS of early L-ARGININE TREAMENT on ENDOTHELIUM in an in Vitro STUDY 33743287

Nature Communications

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis 33772024


Catalog No.

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Applications (RESEARCH USE ONLY!)

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