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SKU:LAA448Bo71

Biotin-Linked Polyclonal Antibody to Insulin (INS)

Biotin-Linked Polyclonal Antibody to Insulin (INS)

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UOM
Concentration
Organism species

Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.

Product No.

LAA448Bo71

Organism Species

Bos taurus; Bovine (Cattle).

Source

Antibody labeling

Ig Type

IgG

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Label

Biotin

Original Antibody

n/a

Buffer Formulation

PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Traits

Liquid

Concentration

500µg/mL

Organism Species More

n/a

Applications

WB; IHC; ICC.

If the antibody is used in flow cytometry, please check FCM antibodies.

UOM

20µl 100µl 200µl 1ml 10ml

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against INS. It has been selected for its ability to recognize INS in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Magazine

Citations

Neuroscience Research

Impaired neural stem/progenitor cell proliferation in Streptozotocin-induced and spontaneous diabetic mice PubMed: 20832431

International Journal of Nanomedicine

Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway PubMed: PMC3770514

Mediators of Inflammation

Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation Pubmed: 24288442

American Journal of Research Communication

Polo Like Kinase 1 (Plk1) Expression in Visceral Adipose Tissue of Morbidly Obese Non Diabetic Women Usa-journals: Source

Nutr Hosp.

Effect of the “protein diet” and bone tissue. Pubmed: 24483972

Endocrinology

Rosiglitazone Inhibits Expression and Secretion of PEDF in Adipose Tissue and Liver of Male SD Rats Via a PPAR-γ Independent Mechanism Endocrine: Source


CORRELA??ES ENTRE METABóLITOS E HORM?NIOS NO PERíODO DE TRANSI??O DE VACAS DE CORTE DE DIFERENTES GENóTIPOS CRIADAS NO SUL DO BRASIL Cnptia:Source


CONCENTRA??ES SéRICAS DE INSULINA NO PóS-PARTO RECENTE DE VACAS DE CORTE DE DIFERENTES GENóTIPOS CRIADAS NO SUL DO BRASIL Alice:Source

Evid Based Complement Alternat Med.

Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats Pubmed:Pmc4363645

Iran J Basic Med Sci

Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats Pubmed:Pmc4046234

Biometals.?

Perinatal low-dose iron treatment influences susceptibility to diet-induced adipogenesis in early-aged male Wistar rats Pubmed:24519243

Asian Pac J Cancer Prev.

Effect of NUCKS-1 Overexpression on cytokine profiling in obese women with breast cancer Pubmed:24568505

J Ethnopharmacol.?

Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial Pubmed:24814037

Obes Surg

Effect of Sleeve Gastrectomy Plus Side-to-Side Jejunoileal Anastomosis for Type 2 Diabetes Control in an Obese Rat Model PubMed: 26202420

Evid Based Complement Alternat Med

Tinospora crispa PubMed: 25821506

international journal of biological and chemical sciences

Taraxacum officinale Index.Php: Ijbcs

FPO

IDENTIFICATION OF MODULATORS OF BINDING PROPERTIES OF ANTIBODIES REACTIVE WITH A MEMBER OF THE INSULIN RECEPTOR FAMILY Y2015: 0301040.Html

Nutrition

Structural and functional abnormalities of hepatic tissues in male Wistar rats fed hyperwhey and super amino anabolic protein Pubmed:27158055

European Journal of Pharmacology

Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3尾 pathway in an amyloid 尾 protein induced alzheimer disease mouse model Pubmed:27131827

Archives of Physiology and Biochemistry

Improvement of oral contraceptive-induced glucose dysreCavia (Guinea pig )lation and dyslipidemia by valproic acid is independent of circulating corticosterone Pubmed:26855320

Archives of Physiology and Biochemistry

Activation of cardiac renin–angiotensin system and plasminogen activator inhibitor-1 gene expressions in oral contraceptive-induced cardiometabolic disorder Pubmed:26934364

Cell and Tissue Research

The dynamic three-dimensional culture of islet-like clusters in decellularized liver scaffolds Pubmed:26796204

Adv Biomed Res.

Trigonella foenum-graecum water extract improves insulin sensitivity and stimulates PPAR and γ gene expression in high fructose-fed insulin-resistant rats pmc:PMC4817393

Mech Ageing Dev. 

Central injection of GALR1 agonist M617 attenuates diabetic rat skeletal muscle insulin resistance through the Akt/AS160/GLUT4 pathway Pubmed:27041232

J Bone Miner Res

Fat and Sucrose Intake Induces Obesity‐Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats Pubmed:26175082

Scientific Reports

Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus pubmed:27461373

International Journal of Medical Research Professionals

Low Circulating Vaspin Level is not associated with Insulinemic Status in Impaired Glucose Tolerant Subjects profile:Muhammad_Saiedullah

Journal of Pharmacy and Nutrition Sciences

Metformin Reduces Oxidative Stress Status and Improves Plasma Insulin Level in Streptozotocin-Induced Diabetic Rats pms:index.php

33

Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome. pubmed:28336389

Journal of Endocrinology and Metabolism

Circulating Betatrophin and Hepatocyte Growth Factor in Type 2 Diabetic Patients: Their Relationship With Disease Prognosis 405

American Journal of Translational Research

Subcutaneous liraglutide ameliorates methylglyoxal-induced Alzheimer-like tau pathology and cognitive impairment by modulating tau hyperphosphorylation and glycogen synthase kinase-3β. pubmed:28337257

Journal of Molecular and Cellular Cardiology

Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese mice pubmed:27638193

Scientific Reports

The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlyingsignaling mechanisms in a rat model of diabetes mellitus. pubmed:27721485

Scientific Reports

Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury throughAMP-activated protein kinase pathway. pubmed:27678302

Biomedicine & Pharmacotherapy

Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylationin diabetic rats. pubmed:27930980

Eur Neuropsychopharmacol.

Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment. pubmed:28063625

Molecular and Cellular Endocrinology

Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway pubmed:28359800

Diabetologia

Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice pubmed:28280902

Biochimica et Biophysica Acta (BBA)-General Subjects

Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats pubmed:28341485

Journal of Diabetes Research

High plasma glucagon levels correlate with waist-to-hip ratio, supra-iliac skinfold thickness, deep subcutaneous abdominal and intra-peritoneal adipose tissue … 2376016.pdf

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES

Berberis integerrima ameliorates insulin resistance in high-fructose-fed insulin-resistant rats pubmed:29147484

Journal of Functional Foods

Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice 10.1016:j.jff.2017.01.044

BMJ Open Diab Res Care

High circulating plasma dipeptidyl peptidase- 4 levels in non-obese Asian Indians with type 2 diabetes correlate with fasting insulin and LDL-C levels, triceps skinfolds, total intra-abdominal adipose tissue volume and presence of diabetes: a case–control study 10.1136:bmjdrc-2017-000393

Archives of Oral Biology

Chronic high-protein diet induces oxidative stress and alters the salivary gland function in rats pubmed:28926744

clinical and experimental pharmacology and physiology

C1q/TNF‐related protein 9 improves the anti‐contractile effects of perivascular adipose tissue via the AMPK‐eNOS pathway in diet‐induced obese mice pubmed:28902432

Cellular Physiology and Biochemistry

Irisin Regulates Heme Oxygenase-1/ Adiponectin Axis in Perivascular Adipose Tissue and Improves Endothelial Dysfunction in Diet-Induced Obese Mice pubmed:28595178

Peptides

Activiated Galanin receptor 2 attenuates insulin resistance in skeletal muscle of obese mice pubmed:29183756

Journal of Diabetes Research

High Plasma Glucagon Levels Correlate with Waist-to-Hip Ratio, Suprailiac Skinfold Thickness, and Deep Subcutaneous Abdominal and Intraperitoneal Adipose Tissue Depots in Nonobese Asian Indian Males with Type 2 Diabetes in North India 10.1155/2017/2376016

Mechanisms of Ageing and Development

Central injection of GALR1 agonist M617 attenuates diabetic rat skeletal muscle insulin resistance through the Akt/AS160/GLUT4 pathway pubmed:27041232

Iranian Journal of Pharmaceutical Research

Antihyperglycemic Effect of Rosa Damascena is Mediated by PPAR.γ Gene Expression in Animal Model of Insulin Resistance pubmed:29201096

Obesity Surgery

Effects of Bariatric Surgery on Change of Brown Adipocyte Tissue and Energy Metabolism in Obese Mice pubmed:28853013

Journal of Current Medical Research and Practice

Relationship between serum leptin concentration and insulin resistance syndrome in patients with type 2 diabetes mellitus issn/2357-0121

Nanomedicine (Lond)

Nanoformulated natural therapeutics for management of streptozotocin-induced diabetes: potential use of curcumin nanoformulation pubmed:28635562

Journal of Inorganic Biochemistry

Synthesis and anti-diabetic activity of new N,N-dimethylphenylenediamine-derivatized nitrilotriacetic acid vanadyl complexes. pubmed:28709620

Obesity surgery

The Effects of Duodenojejunal Omega Switch in Combination with High-Fat Diet and Control Diet on Incretins, Body Weight, and Glucose Tolerance in Sprague-Dawley Rats. pubmed:28840471

Biochemical and Biophysical Research Communications

Adipose tissue complement factor B promotes adipocyte maturation. pubmed:29137982

Oman Medical Journal

The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 Diabetes Mellitus. pubmed:28584599

International Journal of Molecular Medicine

Insulin restores UCP3 activity and decreases energy surfeit to alleviate lipotoxicity in skeletal muscle pubmed:29039450

BMC Complementary and Alternative Medicine

Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin pubmed:28576138

Nutrients

Nypa fruticans Wurmb. Vinegar's Aqueous Extract Stimulates Insulin Secretion and Exerts Hepatoprotective Effect on STZ-Induced Diabetic Rats pubmed:28832548

DARU Journal of Pharmaceutical Sciences

Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway pubmed:29020999

Journal of Traditional and Complementary Medicine

Improvement of spatial learning and memory, cortical gyrification patterns and brain oxidative stress markers in diabetic rats treated with Ficus deltoidea leaf extract and vitexin. pubmed:29322009

World Journal of Pharmaceutical Sciences

The potential role of sitagliptin as an oral treatment regimen for type I diabetes mellitus ISSN: 2321-3086

Journal of Endocrinology

Peripheral insulin resistance in ILK-depleted mice by reduction of GLUT4 expression. pubmed:28490443

Nature Medicine

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis Pubmed:29291351

Surgery for Obesity and Related Diseases

The Effect of Distal-ileal Exclusion After Roux-en-Y Gastric Bypass on Glucose Tolerance and GLP-1 Response in Type-2 Diabetes Sprague-Dawley Rat Model 10.1016:j.soard.2018.07.009

Obesity Surgery 

Preserving Duodenal-Jejunal (Foregut) Transit Does Not Impair Glucose Tolerance and Diabetes Remission Following Gastric Bypass in Type 2 Diabetes Sprague … Pubmed:29098544

Frontiers in Physiology

Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21 Pubmed:29593555

Chemico-Biological Interactions

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats Pubmed:29409856

Journal of Dairy Science

Effects of dietary leucine and phenylalanine on pancreas development, enzyme activity, and relative gene expression in milk-fed Holstein dairy calves Pubmed:29477524

Diabetes research and clinical practice

Beneficial effect of baicalin on insulin sensitivity in adipocytes of diet-induced obese mice Pubmed:29526684

Beneficial Microbes

Anti-obesity properties of the strain subsp. CECT 8145 in Zücker fatty rats Pubmed:29695181

Canadian Journal of Physiology and Pharmacology

Vildagliptin/pioglitazone combination improved the overall glycemic control in type I diabetic rats Pubmed:29510081

Animal Feed Science and Technology

Effects of biotin and nicotinamide supplementation on glucose and lipid metabolism and milk production of transition dairy cows 10.1016:j.anifeedsci.2018.01.012

Journal of Complementary and Integrative Medicine

Diet enriched with fresh coconut decreases blood glucose levels and body weight in normal adults Pubmed:29461972

Experimental and Therapeutic Medicine

Liraglutide exerts a bone‑protective effect in ovariectomized rats with streptozotocin‑induced diabetes by inhibiting osteoclastogenesis Pubmed:29805533

Pakistan Journal of Zoology

Effects of Intrauterine Growth Retardation on Growth, Meat Quality and Muscle Fiber Composition of Pigs. :

Oncotarget

Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver Pubmed:29719598

Journal of King Saud University - Science

The protective effect of Azadirachta excelsa leaves extract and quercetin treatment on the learning and memory impairments in relation with insulin and amylin … 10.1016:j.jksus.2018.05.017

Chinese Journal of Diabetes Mellitus

组织蛋白酶G 在1 型糖尿病小鼠CD+ 4T 淋巴细胞活化过程中的作用. Ebscohost:Source

International Journal of Molecular Sciences

Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice Pubmed: 30231545

Journal of Functional Foods

Transcriptomic analysis reveals effects of fucoxanthin on intestinal glucose transport Doi: 10.1016/j.jff.2018.08.018

Future Medicine

Targeted folate-conjugated pluronic P85/poly(lactide--glycolide) polymersome for the oral delivery of insulin Doi: 10.2217/nnm-2017-0372

Cellular Physiology and Biochemistry

Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice Pubmed: 30308480

Experimental Gerontology

The decline of whole-body glucose metabolism in ovariectomized rats Pubmed: 30292771

Neuroscience Bulletin

Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation Adrenomedullin Receptors in Rats … Pubmed: 30276527

Journal of Cellular Biochemistry

Alterations in lipid peroxidation, lipid profile, insulin sensitivity, and hepatic histopathological changes in diabetic rats following the treatment with Pubmed: 30270568

Biological Rhythm Research

Effects of feeding frequency during lactation in primiparous sows on reproduction performance and diurnal rhythm of endocrine profiles at the weaning-to-ovulation …

Obesity Surgery

The Changes of Serum Metabolites in Diabetic GK Rats after Ileal Transposition Surgery Pubmed: 30397878

Biochimie

Silencing of LncRNA Steroid Receptor RNA Activator attenuates polycystic ovary syndrome in Mice Pubmed: 30391287

Archives of Medical Research

Geniposide and Gentiopicroside Suppress Hepatic Gluconeogenesis via Regulation of AKT-FOXO1 Pathway Pubmed: 30409503

Biomedicine & Pharmacotherapy

Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats Pubmed: 30551463

Journal of Endocrinology

Uterine progesterone signaling is a target for metformin therapy in polycystic ovary syndrome Pubmed: 29535146

West Indian Medical Journal

Plasma Cellular Hypoxia, Mitochondrial Dysfunction, Disease Risk and Prognostic Factors in Type 2 Diabetic Patients in Saudi Arabia.

Biomaterials Science

Enhanced oral absorption of insulin using colon-specific nanoparticles co-modified with amphiphilic chitosan derivatives and cell-penetrating peptides Pubmed: 30672923

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose … Pubmed: 30742994

Obesity Surgery

The Effect of Gastric Bypass with a Distal Gastric Pouch on Glucose Tolerance and Diabetes Remission in Type 2 Diabetes Sprague-Dawley Rat Model Pubmed: 30778846

Journal of Alzheimer's Disease Reports

Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer's Disease in Rats

Stress

Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure Pubmed: 30821572

Life Sciences

Interrelation of liver vascularity to non-alcoholic fatty liver through a comparative study of the vasodilator effect of carvedilol or nicorandil in rats Pubmed: 30826497

cell biology international

Regulation of insulin resistance by targeting insulin‐like growth factor 1 receptor (IGF‐1R) with microRNA‐122‐5p in hepatic cells Pubmed: 30958584

international journal of molecular sciences

Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice Pubmed: 30909542

Journal of Clinical and Translational Endocrinology

Dobesity: relationship between vitamin d deficiency, obesity and sclerostin as a novel biomarker of bone metabolism

Acta Pharmacologica Sinica

Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice Pubmed: 31213670

Biochemistry

Protective Effect of Peroxiredoxin 6 Against Toxic Effects of Glucose and Cytokines in Pancreatic RIN-m5F β-Cells

Physiological Research

Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis. Pubmed: 31301730

molecular nutrition & food research

Glycerol Monolaurate‐Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High Fat diet‐fed Mice Pubmed: 31318165

Arch Physiol Biochem

Associations of apelin, leptin, irisin, ghrelin, insulin, glucose levels, and lipid parameters with physical activity during eight weeks of regular exercise training Pubmed: 31290696


Efeito do consumo crônico de óleo de coco sobre parâmetros bioquímicos e do status redox em ratas saudáveis.

Diabetes-Metabolism Research and Reviews

Liraglutide Combined with Human Umbilical Cord Mesenchymal Stem Cell Transplantation inhibits beta‐cells apoptosis via mediating the ASK1/JNK/BAX pathway in Pubmed: 31411368

Phytomedicine

Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway

Naunyn-Schmiedebergs Archives of Pharmacology

Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway Pubmed: 31420722

Nutrients

High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights …

Cells

MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model Pubmed: 31540304

Molecular and cellular endocrinology

Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway Pubmed: 31647955

Obesity Surgery

Duodenal-Jejunal Bypass Ameliorates Type 2 Diabetes Mellitus by Activating Insulin Signaling and Improving Glucose Utilization in the Brain Pubmed: 31605365

Surgical Endoscopy and Other Interventional Techniques

Distal gastric mucosa ablation induces significant weight loss and improved glycemic control in type 2 diabetes Sprague–Dawley rat model Pubmed: 31630290

Biomedicine & Pharmacotherapy

Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats Pubmed: 31545258

International Journal of Endocrinology

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling Pubmed: 31662747

Food & Function

Depolymerized RG-I enriched pectin from citrus segment membrane modulates gut microbiota, increases SCFAs production, promotes the growth of Bifidobacterium … Pubmed: 31778135

Life Sciences

P-Coumaric acid alleviates experimental diabetic nephropathy through modulation of toll like receptor-4 in rats Pubmed: 31629762

Journal of Ovarian Research

Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase Pubmed: 31722718

journal of ethnopharmacology

Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig model Pubmed: 31756448

Brain Research

Isoflurane aggravates peripheral and central insulin resistance in high-fat diet/streptozocin-induced type 2 diabetic mice Pubmed: 31672472

Journal of Ethnopharmacology

San-Huang-Tang protects obesity/diabetes induced NAFLD by upregulating PGC-1α/PEPCK signaling in obese and galr1 knockout mice models Pubmed: 31843573

Journal of Hazardous Materials

Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice Pubmed: 31796355

Journal of Steroid Biochemistry and Molecular Biology

SerpinB1 promotes the proliferation of porcine pancreatic stem cells through the STAT3 signaling pathway Pubmed: 31785377

Journal of dermatological treatment

Liraglutide improved inflammation via mediating IL-23/Th-17 pathway in obese diabetic mice with psoriasiform skin Pubmed: 31868553

Nutrients

Rotundic Acid Protects against Metabolic Disturbance and Improves Gut Microbiota in Type 2 Diabetes Rats Pubmed: 31887996

JOURNAL OF DAIRY SCIENCE

Decreased amylolytic microbes of the hindgut and increased blood glucose implied improved starch utilization in the small intestine by using rumen-protected leucine … Pubmed: 32113753

Biomed Pharmacother

Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice Pubmed: 32035395

Frontiers in Endocrinology

Hyperbaric oxygen ameliorates insulin sensitivity by increasing GLUT4 expression in skeletal muscle and stimulating UCP1 in brown adipose tissue in T2DM … Pubmed: 32082261

Cell Physiol Biochem

Integrin Linked Kinase (ILK) Downregulation as an Early Event During the Development of Metabolic Alterations in a Short-Term High Fat Diet Mice Model. Pubmed: 31972071

JOURNAL OF FOOD SCIENCE

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats Pubmed: 32249934

Journal of Diabetes Research

Roux-en-Y Gastric Bypass in Obese Diabetic Rats Promotes Autophagy to Improve Lipid Metabolism through mTOR/p70S6K Signaling Pathway Pubmed: 32309446

Brain Research

Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway Pubmed: 32304687

endocrine journal

Mice with nucleus tractus solitarius injury induced by chronic restraint stress present impaired ability to raise blood glucose and glucagon levels when blood glucose … Pubmed: 32249244

Frontiers in Endocrinology

RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis Pubmed: 32328034

Antioxidants

Effects of Allicin on Pathophysiological Mechanisms during the Progression of Nephropathy Associated to Diabetes Pubmed: 33203103

Nature Communications

AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis Pubmed: 33199780

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of the hypoglycemic effect of exendin-4's new oral self-nanoemulsifying system in rats Pubmed: 33197556

BIOLOGICAL RESEARCH

Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance … Pubmed: 33109277

FASEB JOURNAL

Irradiation of carotid baroreceptor with low‐intensity pulsed ultrasound exerts different metabolic protection in perirenal, epididymal white adipose tissue and … Pubmed: 32954574

Biol Res

Palmatine ameliorates high fat diet induced impaired glucose tolerance Pubmed: 32928312

ENDOCRINE

Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction Pubmed: 32892310

DIABETOLOGIA

Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via … Pubmed: 32880686

AMERICAN JOURNAL OF PATHOLOGY

Insulin promotes corneal nerve repair and wound healing in type 1 diabetic mice by enhancing Wnt/β-catenin signaling Pubmed: 32858016

MEDIATORS OF INFLAMMATION

Aplysin Retards Pancreatic Necrosis and Inflammatory Responses in NOD Mice by Stabilizing Intestinal Barriers and Regulating Gut Microbial Composition Pubmed: 32801992

EUROPEAN JOURNAL OF PHARMACOLOGY

Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways Pubmed: 32758573

ARCHIVES OF GYNECOLOGY AND OBSTETRICS

MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance Pubmed: 32757043

CHEMICO-BIOLOGICAL INTERACTIONS

Modulatory role of imatinib mesylate on pancreatic β-cells' secretory functions in an STZ rat model of diabetes mellitus Pubmed: 32710900

Mol Med

Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic … Pubmed: 32698821

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Highly Branched RG-I Domain Enrichment are Indispensable for Pectin Mitigating Against High-Fat Diet-Induced Obesity Pubmed: 32633953

Scientific Reports

Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in rats Pubmed: 32616735

J Endocrinol Invest

Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats Pubmed: 32588381

J Chem Neuroanat

The neuroprotective effect of simvastatin on the cerebellum of experimentally-induced diabetic rats through klotho upregulation: An immunohistochemical study Pubmed: 32479899

Journal of Diabetes Research

Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus Pubmed: 33123597

Journal of Cellular and Molecular Medicine

Cooperative effects of galanin and leptin on alleviation of insulin resistance in adipose tissue of diabetic rats Pubmed: 32395890

BioMed Research International

Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress Pubmed: 32685488

Frontiers in Pharmacology

MiR-185-5p Protects Against Angiogenesis in Polycystic Ovary Syndrome by Targeting VEGFA Pubmed: 32760272

Iranian Journal of Basic Medical Sciences

Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS

Nutrition & Metabolism

Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut …

Journal of Functional Foods

Different source of commercial vegetable oils may regulate metabolic, inflammatory and redox status in healthy rats


Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds


The effects of different intensity endurance and resistance exercise on diabetic-related blood profiles in impaired glucose tolerance mice

Cell Death & Disease

Phosphorylation of eIF2¦Á signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner 33318479

Ther Adv Chronic Dis

Empagliflozin improves chronic hypercortisolism-induced abnormal myocardial structure and cardiac function in mice 33294147

Physiol Behav

Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1¦Á expression and activity 33412190

PLoS Genetics

Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirds 33370292

Mol Med Rep

N1?methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC?1¦Á signaling pathway 33576435

Arch Endocrinol Metab

Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study 33740335

Sci Rep

Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl: ZUC (ORL)-Lepr fa) rats 33833309

PeerJ

miR-155-5p upregulation ameliorates myocardial insulin resistance via mTOR signaling in chronic alcohol drinking rats 33868799

JOURNAL OF FOOD BIOCHEMISTRY

Identification of curcumin as a potential ¦Á©\glucosidase and dipeptidyl©\peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation 33817806

JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver?¡­ 33915261

Cell Metab

TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease 34107313


Dapagliflozin: a Sodium-glucose Cotransporter 2 Inhibitor, Attenuates Angiotensin II-induced Cardiac Fibrotic Remodeling by Regulating TGF¦Â1/Smad ¡­ 34116674

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Different Ratios of Corn and Coconut Oil Blends in High©\Fat Diets Influence Fat Deposition without Altering Metabolic Biomarkers in Male Rats

Journal of Alzheimer's disease

DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Up-regulating cAMP/PKA/CREB?¡­

International Journal of Diabetes in Developing Countries

Investigation of extracellular matrix genes associated with Alzheimer's disease in the hippocampus of experimental diabetic model rats

researchsquare

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Cells Tissues Organs

Intermittent Fasting Attenuates High Fat Diet-Induced Cerebellar Changes in Rats: Involvement of TNFα, autophagy and oxidative stress 34551416

Experimental Biology and Medicine

Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats 34550826

Phytomedicine

Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling 34923235

Pharmacol Res

Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability 34896249

Eat Weight Disord

Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice 34370270

Food Chem Toxicol

Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats 34329744

Eur J Pharmacol

Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor Pubmed:34973950

Surgical Endoscopy

The effect of bariatric surgery on the expression of Growth Differentiation Factor-15/Macrophage-Inhibitory Cytokine-1 (GDF-15/MIC-1) in rat Pubmed:35029766

Arch Biochem Biophys

ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice Pubmed:34990584

Environ Sci Pollut Res Int

Environmental exposure to low-dose perfluorohexanesulfonate promotes obesity and non-alcoholic fatty liver disease in mice fed a high-fat diet Pubmed:35217953

Naunyn Schmiedebergs Arch Pharmacol

Intragastric safflower yellow and its main component HSYA improve leptin sensitivity before body weight change in diet-induced obese mice Pubmed:35201390

PLoS One

A cross-sectional comparative study on the effects of body mass index and exercise/sedentary on serum asprosin in male college students Pubmed:35381008

Cell Death & Disease

Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance Pubmed:35347118

Endocr J

A novel anti-obesity mechanism for liraglutide by improving adipose tissue leptin resistance in high-fat diet-fed obese mice Pubmed:35705299

Antioxidants

Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice Pubmed:35740008

Mol Cell Endocrinol

Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2 Pubmed:35654225

Biofabrication

Dual-core coaxial bioprinting of double-channel constructs with a potential for perfusion and interaction of cells Pubmed:35616388

Ecotoxicology and Environmental Safety

Constitutional delay of growth and puberty in female mice is induced by circadian rhythm disruption in utero Pubmed:35679725

SAUDI J BIOL SCI

Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain … Pubmed:35531250

Saudi Pharmaceutical Journal

Sukkari dates seed improves type-2 diabetes mellitus-induced memory impairment by reducing blood glucose levels and enhancing brain cholinergic … Pubmed:35812141

Turk J Diab Obes

An Investigation of the Effect of Curcumin on Fructose-Induced Metabolic Syndrome Rat Models

Journal of Drug Delivery Science and Technology

Miglitol-PMO nanoparticles, an alpha-glucosidase inhibitor, has prolonged action on blood glucose level in diabetic rats

Genes & Diseases

Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue


Catalog No.

Related products for research use of Bos taurus; Bovine (Cattle) Organism species

Applications (RESEARCH USE ONLY!)

RPA448Bo01

Recombinant Insulin (INS)

Positive Control; Immunogen; SDS-PAGE; WB.

APA448Bo01

Active Insulin (INS)

Cell culture; Activity Assays.

CPA448Bo21

OVA Conjugated Insulin (INS)

Immunogen; SDS-PAGE; WB.

PAA448Bo01

Polyclonal Antibody to Insulin (INS)

WB; IHC; ICC; IP.

LAA448Bo71

Biotin-Linked Polyclonal Antibody to Insulin (INS)

WB; IHC; ICC.

MAA448Bo21

Monoclonal Antibody to Insulin (INS)

WB; IHC; ICC; IP.

CEA448Bo

ELISA Kit for Insulin (INS)

Enzyme-linked immunosorbent assay for Antigen Detection.

LMA448Bo

Magnetic Luminex Assay Kit for Insulin (INS) ,etc.

Magnetic Luminex Assay for Antigen Detection.

 

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