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SKU:LAB438Ra71

Biotin-Linked Polyclonal Antibody to Tyrosine Hydroxylase (TH)

Biotin-Linked Polyclonal Antibody to Tyrosine Hydroxylase (TH)

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UOM
Concentration
Organism species

Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.

Product No.

LAB438Ra71

Organism Species

Rattus norvegicus (Rat).

Source

Antibody labeling

Ig Type

IgG

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Label

Biotin

Original Antibody

n/a

Buffer Formulation

PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Traits

Liquid

Concentration

500µg/mL

Organism Species More

n/a

Applications

WB; IHC; ICC.

If the antibody is used in flow cytometry, please check FCM antibodies.

UOM

20µl 100µl 200µl 1ml 10ml

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against TH. It has been selected for its ability to recognize TH in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Magazine

Citations

Mol Neurobiol.

1, 25-dyhydroxyvitamin D3 Attenuates l-DOPA-Induced Neurotoxicity in Neural Stem Cells Pubmed:25102940

PLOS ONE

Genetic Diagnosis of Two Dopa-Responsive Dystonia Families by Exome Sequencing Pubmed:25181484

biomedicine & pharmacotherapy

Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. pubmed:28199883

Therapeutics and Clinical Risk Management

Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGFβ1, and TNFα associated with high-altitude pulmonary edema in an Indian population. pubmed:27540296

Sci Rep. 

Silencing salusin-β attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats. pubmed:28230187

Journal of Cellular Biochemistry

Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats pubmed:28681939

Environmental Science & Technology

Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate Pubmed:29565584

Molecular Neurobiology

Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model Pubmed:29429051

Chemosphere

Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae Pubmed:29407805

Neurospine

The Effect of Recombinant Tyrosine Hydroxylase Expression on the Neurogenic Differentiation Potency of Mesenchymal Stem Cells Pubmed:29656620

Toxicology and Applied Pharmacology

Montelukast attenuates rotenone-induced microglial activation/p38 MAPK expression in rats: Possible role of its antioxidant, anti-inflammatory and antiapoptotic effects Pubmed: 30222980

International Journal Of Cardiology

Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus Pubmed: 30581101

Behavioural Brain Research

Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition

Environment International

Perfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption Pubmed: 31733528

Environmental Pollution

Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae Pubmed: 31935612

International Journal of Pharmacology

Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease Pubmed: 32084576

comparative biochemistry and physiology c-toxicology & pharmacology

Thyroid disruption and developmental toxicity caused by Cd2+ in Schizopygopsis younghusbandi larvae Pubmed: 32344129

International Journal of Stem cell Research & Therapy

Selection of Cells for Parkinson's Disease Cell-Therapy

Ecotoxicol Environ Saf

Effects of SiO2 nanoparticles on the uptake of tetrabromobisphenol A and its impact on the thyroid endocrine system in zebrafish larvae 33385677

Nutr Res

Tocotrienols protect differentiated SH-SY5Y human neuroblastoma cells against 6-hydroxydopamine-induced cytotoxicity by ameliorating dopamine biosynthesis and … Pubmed:35065349

Food Chem Toxicol

Omarigliptin attenuates rotenone-induced Parkinson's disease in rats: Possible role of oxidative stress, endoplasmic reticulum stress and immune modulation Pubmed:35439590

Food Chemistry: Molecular Sciences

Unravelling the neuroprotective mechanisms of carotenes in differentiated human neural cells: biochemical and proteomic approaches Pubmed:35415676

Journal of Environmental Sciences

Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2, 4, 6-tribromophenol


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