Cloud-clone
SKU:LAB979Hu81
FITC-Linked Polyclonal Antibody to Hepcidin (Hepc)
FITC-Linked Polyclonal Antibody to Hepcidin (Hepc)
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Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.
Product No.
LAB979Hu81
Organism Species
Homo sapiens (Human).
Source
Antibody labeling
Ig Type
IgG
Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Label
FITC
Original Antibody
n/a
Buffer Formulation
PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Traits
Liquid
Concentration
500µg/mL
Organism Species More
n/a
Applications
WB; IHC; ICC; IF.
If the antibody is used in flow cytometry, please check FCM antibodies.
UOM
20µl 100µl 200µl 1ml 10ml
SPECIFITY
The antibody is a rabbit polyclonal antibody raised against Hepc. It has been selected for its ability to recognize Hepc in immunohistochemical staining and western blotting.
USAGE
Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.
STORAGE
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
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Magazine |
Citations |
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World J Gastroenterol. |
Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats Pubmed: 24764672 |
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International Journal of Advanced Research |
Modulations of serum hepcidin, IL6 and iron status by different exercise regimens in ovarectomized rats Com:Source |
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Neurochemical Journal |
Serum iron metabolism markers including hepcidin in multiple sclerosis patients Springer:Source |
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Afro-Egypt J Infect Endem Dis |
Monitoring Hepcidin Level in Chronic Hepatitis C Virus Patients during Therapy Zu:Source |
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Gastroenterology |
Gluconeogenic signals regulate iron homeostasis via hepcidin in mice Pubmed:Pmc3989026 |
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J Card Fail. |
Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency Pubmed:24440572 |
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Food Funct. |
The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia Pubmed:24752529 |
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Free Radic Res. |
Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation Pubmed:25175826 |
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Saudi J Kidney Dis Transpl. |
Hepcidin and regulation of iron homeostasis in maintenance hemodialysis patients Pubmed:25193892 |
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J Endocrinol Invest.? |
The interplay among iron metabolism, endothelium and inflammatory cascade in dysmetabolic disorders Pubmed:25245337 |
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Gastroenterology Research and Practice |
An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel Disease Pubmed:25628652 |
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Clin Lab. |
Serum hepcidin levels in Bulgarian population. Pubmed:25651734 |
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The Tohoku Journal of Experimental Medicine |
Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia Pubmed:25742771 |
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Cancer Res |
Hepcidin regulation in prostate and its disruption in prostate cancer PubMed: 25858146 |
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Biochem Biophys Res Commun |
B-cell translocation gene 2 promotes hepatic hepcidin production via induction of Yin Yang 1 PubMed: 25839654 |
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Blood Purif |
Effect of a More Permeable Dialysis Membrane on ESA Resistance in Hemodialysis Patients - A Pilot Investigation PubMed: 26536083 |
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Asian Journal of Clinical Nutrition |
Urinary Hepcidin in Diagnosis of Iron Deficiency Anemia Openview: E01Ad7C4A9109Ed5Fadb03Ec206D7Bdc |
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Front Psychol |
Ferrous sulfate, but not iron polymaltose complex, aggravates local and systemic inflammation and oxidative stress in dextran sodium sulfate-induced colitis in rats PubMed: 25852597 |
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Biol Trace Elem Res |
Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin PubMed: 25774043 |
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APS Journals |
Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal copper, high fructose diet in male rats. PubMed: 25813056 |
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European Journal of Haematology |
Hepcidin in tumor‐related iron deficiency anemia and tumor‐related anemia of chronic disease: pathogenic mechanisms and diagnosis PubMed: 24954786 |
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WJA |
The Effects of Treatment on Serum Hepcidin and Iron Homeostasis in HIV-1-Infected In-dividuals Journal: 59107 |
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Nutrition, Metabolism and Cardiovascular Diseases |
Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case-control study. Pubmed:27139516 |
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Food Funct |
The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice Pubmed:26757699 |
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Antioxid Redox Signal. |
Hydrogen sulfide attenuates inflammatory hepcidin by reducing IL-6 secretion and promoting SIRT1-mediated STAT3 deacetylation Pubmed:26154696 |
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BioMed Research International |
The Impact of Acute Matriptase Inhibition in Hepatic Inflammatory Models. pubmed:27642598 |
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Frontiers in Neuroscience |
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution. pubmed:27729845 |
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Experimental Biology and Medicine |
Effects of iron supplementation in mice with hypoferremia induced by obesity pubmed:27439539 |
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Nutrition, Metabolism and Cardiovascular Diseases |
Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case–control study pubmed:27139516 |
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PLOS ONE |
S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway. pubmed:27649298 |
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Endocrine connections |
Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expression pubmed:28179377 |
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Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infants publication:305921433_Maternal_and_cord_blood_hepc |
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Oxidative Medicine and Cellular Longevity |
Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation pubmed:29147463 |
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The Royal Society of Chemistry |
Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression DOI: 10.1039/C7RA09576G |
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Journal of Inflammation |
Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients 10.1186:s12950-017-0166-3 |
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Antioxidants and Redox Signaling |
AMPK serves as a Therapeutic Target against Anemia of Inflammation pubmed:27923278 |
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NutriciónHospitalaria |
Micronutrient supplementation in gastric bypass surgery: prospective study on infl ammation and iron metabolism in premenopausal women 10.20960/nh.1162 |
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The Japanese Society of Hematology |
Hepcidin suppression in β‑thalassemia is associated with the down‑regulation of atonal homolog 8 pubmed:28405918 |
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Tuberculosis |
Modulation of iron status biomarkers in tuberculosis-diabetes co-morbidity 10.1016/j.tube.2017.11.011 |
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Oman Medical Journal |
The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 Diabetes Mellitus. pubmed:28584599 |
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Cellular Physiology and Biochemistry |
The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron Metabolism by Regulating Hepcidin in Tumor-Bearing Mice Pubmed:29843136 |
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Cellular Microbiology |
inhibits ferroportin translation by modulating FBXL5‐IRP2 axis for its growth within host macrophages Pubmed:29470856 |
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Journal of Histochemistry & Cytochemistry |
Acute and Chronic Iron Overloading Differentially Modulates the Expression of Cellular Iron-homeostatic Molecules in Normal Rat Kidney Pubmed:29873589 |
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Clinical and Experimental Medicine |
Increased NGAL level associated with iron store in chronic kidney disease with anemia Pubmed:29909502 |
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Hematology |
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? Pubmed:29318945 |
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Hepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individuals 77856 |
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Food & Function |
Effect of iron supplement from microalgae on the treatment of iron-deficient anemia in rats Doi: 10.1039/C8FO01696H |
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Haematologica |
New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia Pubmed: 30792208 |
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Ann Intensive Care |
Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational study Pubmed: 31183575 |
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Journal of Functional Foods |
Dietary gelatin enhances non-heme iron absorption possibly via regulation of systemic iron homeostasis in rats |
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Naunyn Schmiedebergs Arch Pharmacol. |
3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitro Pubmed: 31659405 |
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DEVELOPMENT GROWTH & DIFFERENTIATION |
H2O2 induces oxidative stress damage through the BMP‐6/SMAD/hepcidin axis Pubmed: 32012242 |
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Frontiers in Physiology |
Increased Hepcidin Levels During a Period of High Training Load Do Not Alter Iron Status in Male Elite Junior Rowers Pubmed: 32038278 |
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J Korean Med Sci |
Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients? Pubmed: 32174062 |
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nephrology dialysis transplantation |
Iron kinetics following treatment with sucroferric oxyhydroxide or ferric citrate in healthy rats and models of anaemia, iron overload or inflammation Pubmed: 32259248 |
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mikrochimica acta |
Gold-silver core-shell nanoparticle–based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidin Pubmed: 33095336 |
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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY |
Circulating Osteocyte‐Related Biomarkers (vitamin D, sclerostin, dickkopf-1), hepcidin, and oxidative stress markers in early breast cancer: their impact in … Pubmed: 33065276 |
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Sleep Breath |
Relation of serum hepcidin levels and restless legs syndrome in chronic hemodialysis patients Pubmed: 33029690 |
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journal of trace elements in experimental medicine |
Difference in iron metabolism may partly explain sex-related variability in the manifestation of Wilson's disease Pubmed: 32937238 |
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reproduction in domestic animals |
Expression of iron regulatory proteins in full term swine placenta Pubmed: 32449967 |
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Neurobiology of Aging |
Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female mice Pubmed: 32920472 |
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The Egyptian Journal of Haematology |
Urinary hepcidin concentration in assessment of iron homeostasis in pediatrics |
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COMPARATIVE MONITORING OF THE ENZYME ACTIVITY OF BONE METABOLISM IN PATIENTS AFTER DENTAL IMPLANTATION |
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Serum iron, prealbumin, D-dimer and prothrombin time are indicators of the diagnosis, severity and outcome of Salmonella enterica serovar Enteritidis infection |
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Гепсидин и индекс фиброза печени MELD-XI как маркеры полиорганной недостаточности у пациентов хронической сердечной недостаточностью с … |
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Ассоциации уровней NT-proBNP и гепсидина с клинико-лабораторными параметрами у больных хронической сердечной недостаточностью с разной … |
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Biosci Rep |
Correlation of hepcidin and serum ferritin levels in thalassemia patients at Chiang Mai University Hospital 33565577 |
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Biometals |
Iron metabolism is disturbed and anti-copper treatment improves but does not normalize iron metabolism in Wilson's disease 33555495 |
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J Mol Cell Cardiol |
Systemic iron deficiency does not affect the cardiac iron content and progression of heart failure 34139233 |
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Continuous Veno-Venous Hemofiltration (CVVH) Improves Iron Metabolism Disorders in Patients With Sepsis: A Single-Center Prospective Cohort Study |
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Reports of Biochemistry & Molecular Biology |
Evaluation of Serum Cyclooxygenase, Hepcidin Levels in Acute Renal Injury (AKI) Patients Following Cardiac Catheterization |
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Food Funct |
High-dose ferric citrate supplementation attenuates omega-3 polyunsaturated fatty acid biosynthesis via downregulating delta 5 and 6 desaturases in rats with high-fat … 34787162 |
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J Trace Elem Med Biol |
Caffeine and alcohol-friends or foes of human iron stores? Pubmed:35063815 |
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PeerJ |
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis Pubmed:35698613 |
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Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet's Disease |
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Food Bioscience |
Roles of homopolymeric apoferritin in alleviating alcohol-induced liver injury |
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