Cloud-clone
SKU:LAH757Mu81
FITC-Linked Polyclonal Antibody to Klotho (KL)
FITC-Linked Polyclonal Antibody to Klotho (KL)
Couldn't load pickup availability
Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.
Product No.
LAH757Mu81
Organism Species
Mus musculus (Mouse).
Source
Antibody labeling
Ig Type
IgG
Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Label
FITC
Original Antibody
n/a
Buffer Formulation
PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Traits
Liquid
Concentration
500µg/mL
Organism Species More
n/a
Applications
WB; IHC; ICC; IF.
If the antibody is used in flow cytometry, please check FCM antibodies.
UOM
20µl 100µl 200µl 1ml 10ml
SPECIFITY
The antibody is a rabbit polyclonal antibody raised against KL. It has been selected for its ability to recognize KL in immunohistochemical staining and western blotting.
USAGE
Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.
STORAGE
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
|
Magazine |
Citations |
|
Life Sciences |
High phosphate feeding induced arterial medial calcification in uremic rats: Roles of Lanthanum carbonate on protecting vasculature Pubmed: 24012609 |
|
EXPERIMENTAL & CLINICAL CARDIOLOGY |
Sick Sinus Syndrome May Attribute to the Decrease of ?±-klotho Protein in Mice Com:Source |
|
Int J Clin Exp Pathol.? |
α-Klotho is an acute phase protein and altered by restraint stress in mice Pubmed:Pmc4203207 |
|
Annales de Biologie Clinique |
Les biomarqueurs des calcifications vasculaires PubMed: 26069069 |
|
Mol Med Rep |
Effect of secondary hyperparathyroidism serum on endothelial cells and intervention with Klotho PubMed: 25873020 |
|
Calcif Tissue Int |
Human Preosteoblastic Cell Culture from a Patient with Severe Tumoral Calcinosis-Hyperphosphatemia Due to a NewGALNT3 PubMed: 25899975 |
|
中华内分泌代谢杂志 |
抗衰老蛋白Klotho 阻断高糖培养的大鼠肾小球系膜细胞TLR4/NF-κB p65/NGAL 通路的激活及其作用机制 Cn: Article |
|
Mol Cell Endocrinol |
The function of miR-199a-5p/Klotho regulating TLR4/NF-κB p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism PubMed: 26419931 |
|
Arch Med Sci |
Soluble Klotho protein as a novel serum biomarker in patients with acromegaly pmc:PMC4754356 |
|
Am J Nephrol |
Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway Pubmed:27174564 |
|
Sci Rep. |
Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice. pubmed:28387374 |
|
Nephrology |
Is there a role for newer biomarkers in chronic kidney disease-mineral and bone disorder management? pubmed:28429560 |
|
Journal of Integrative Nephrology & Andrology |
Associations between serum fibroblast growth factor 23 level and intradialytic hypotension in hemodialysis patients issn:2394-2916 |
|
International Journal of Clinical and Experimental Pathology |
Protective effect of restructuring klotho protein combined with trimetazidine on myocardial injury in mice ISSN:1936-2625 |
|
Journal of veterinary medical science |
Changes of Klotho protein and Klotho mRNA expression in a hydroxy-L-proline induced hyperoxaluric rat model pubmed:28943597 |
|
Cellular Physiology and Biochemistry |
Klotho Reduces Necroptosis by Targeting Oxidative Stress Involved in Renal Ischemic-Reperfusion Injury Pubmed:29550818 |
|
American Journal of Translational Research |
Advanced maternal age impairs spatial learning capacity in young adult mouse offspring Pubmed:29636887 |
|
Journal of Diabetes and its Complications |
Clinical implication of alterations in serum Klotho levels in patients with type 2 diabetes mellitus and its associated complications Pubmed:30042059 |
|
Medical Science Monitor |
Klotho Inhibits Proliferation and Migration of Angiotensin II-Induced Vascular Smooth Muscle Cells (VSMCs) by Modulating NF-κB p65, Akt, and Extracellular Signal … Pubmed:30004089 |
|
Nephrology Dialysis Transplantation |
High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease Pubmed: 30189026 |
|
BMC Nephrology |
The role of klotho in chronic kidney disease Pubmed: 30348110 |
|
Nature Communications |
Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration Pubmed: 30451844 |
|
Kidney International |
Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome Pubmed: 30770217 |
|
Expert Opinion on Therapeutic Targets |
The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism and bone health in uremic rats Pubmed: 30801205 |
|
Mol Immunol |
CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection Pubmed: 33223223 |
|
Journal of Clinical Hypertension |
Effects of salt intervention on serum levels of Klotho influenced by salt sensitivity Pubmed: 33164306 |
|
CURRENT EYE RESEARCH |
Expression of α-Klotho is downregulated and associated with oxidative stress in the lens in streptozotocin-induced diabetic rats Pubmed: 32744464 |
|
international immunopharmacology |
Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats Pubmed: 32438076 |
|
Purinergic Signalling |
P2X7 siRNA targeted to the kidneys increases klotho and delays the progression of experimental diabetic nephropathy. Pubmed: 32377919 |
|
Oxidative Medicine and Cellular Longevity |
Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury Pubmed: 33123314 |
|
NEUROSCIENCE |
Increased Plasma Level of Longevity Protein Klotho as a Potential Indicator of Cognitive Function Preservation in Patients With Schizophrenia Pubmed: 32612508 |
|
Pharmacological Reports |
¦ÁKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy 33675964 |
|
J Mol Neurosci |
Investigation of the Role of Induced Overexpression of the Isolated Secreted Klotho on the A-172 Human Glioblastoma Cells Pubmed:35112226 |
|
Reproductive Biology and Endocrinology |
Expression of Klotho in Follicles of Patients With Polycystic Ovary Syndrome and Its Clinical Significance |
|
Journal of Ovarian Research |
Klotho is a prognostic indicator of oocytes qualities in polycystic ovary syndrome |
|
Catalog No. |
Related products for research use of Mus musculus (Mouse) Organism species |
Applications (RESEARCH USE ONLY!) |
|
RPH757Mu02 |
Positive Control; Immunogen; SDS-PAGE; WB. |
|
|
RPH757Mu01 |
Positive Control; Immunogen; SDS-PAGE; WB. |
|
|
PAH757Mu02 |
WB; IHC; ICC; IP. |
|
|
PAH757Mu01 |
WB; IHC; ICC; IP. |
|
|
LAH757Mu71 |
WB; IHC; ICC. |
|
|
LAH757Mu81 |
WB; IHC; ICC; IF. |
|
|
SEH757Mu |
Enzyme-linked immunosorbent assay for Antigen Detection. |
|
|
WEH757Mu |
Enzyme-linked immunosorbent assay for Antigen Detection. |
|
|
SCH757Mu |
Chemiluminescent immunoassay for Antigen Detection. |
|
|
LMH757Mu |
Magnetic Luminex Assay for Antigen Detection. |
|
|
KSH757Mu01 |
Main materials for "Do It(ELISA Kit) Yourself" |
Share
