Cloud-clone
SKU:MAA388Hu21
Monoclonal Antibody to Complement Component 5a (C5a)
Monoclonal Antibody to Complement Component 5a (C5a)
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Western blotting: 0.5-3µg/mL
;Immunohistochemistry: 5-30µg/mL
;Immunocytochemistry: 5-30µg/mL
;Optimal working dilutions must be determined by end user.
Product No.
MAA388Hu21
Organism Species
Homo sapiens (Human).
Source
Monoclonal antibody preparation
Host
Mouse
Potency (Clone Number)
D2
Ig Isotype
IgG2b Kappa
Purification
Protein A + Protein G affinity chromatography
Label
None
Immunogen
RPA388Hu01-Recombinant Complement Component 5a (C5a)
Buffer Formulation
0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Traits
Liquid
Concentration
1mg/ml
Organism Species More
Rattus norvegicus (Rat)
Applications
WB,IHC
If the antibody is used in flow cytometry, please check FCM antibodies.
UOM
20µl 100µl 200µl 1ml 10ml
SPECIFITY
The antibody is a mouse monoclonal antibody raised against C5a. It has been selected for its ability to recognize C5a in immunohistochemical staining and western blotting.
USAGE
Western blotting: 0.01-3µg/mL
Optimal working dilutions must be determined by end user.
STORAGE
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
| Magazine | Citations |
| Molecular Immunology | Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro ScienceDirect: S0161589011008297 |
| Journal of Reproductive Immunology | Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia PubMed: 23415845 |
| The Journal of Clinical Investigation | Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis PubMed: PMC3195471 |
| Journal of Antimicrobial Chemotherapy | Efficacy of a synthetic antimicrobial peptidomimetic versus vancomycin in a Staphylococcus epidermidis device-related murine peritonitis model Pubmed: 23645587 |
| Journal of Orthopaedic Research | Conversion from external fixator to intramedullary nail causes a second hit and impairs fracture healing in a severe trauma model Pubmed: 23070742 |
| SpringerPlus | Therapeutic effects of sesame oil on monosodium urate crystal-induced acute inflammatory response in rats Pubmed: 24353977 |
| American Journal fo Reproductive Immunology | Evaluation of the Markers of Inflammation in the Umbilical Cord Blood of Newborns of Mothers with Thrombophilia Pubmed:25209155 |
| Gynecol Obstet Invest | Complement Split Products C3a/C5a and Receptors: Are They Regulated by Circulating Angiotensin II Type 1 Receptor Autoantibody in Severe Preeclampsia? PubMed: 26485247 |
| Journal of Neuroimmunology | Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis Pubmed:27235358 |
| International Immunopharmacology | Consistency and pathophysiological characterization of a rat polymicrobial sepsis model via the improved cecal ligation and puncture surgery Pubmed:26802602 |
| Digital Repository | Dosagem de frações ativadas do sistema complemento em empiema induzido em ratos 10183 |
| Environmental Pollution | Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia pubmed:27511439 |
| Cancer Letters | Complement C5a/C5aR pathway potentiates the pathogenesis Q5 of gastric cancer by down-regulating p21 expression pubmed:29031586 |
| Acta Paediatrica | Serum complement factor 5a levels are associated with nonalcoholic fatty liver disease in obese children DOI: 10.1111/apa.14106 |
| Scientific Reports | Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis Pubmed: 30291296 |
| Nutrients | The Beneficial Effects of Lactobacillus plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes Pubmed: 30736479 |
| Journal of NeuroVirology | Intrathecal complement activation by the classical pathway in tick-borne encephalitis Pubmed: 30850976 |
| PLoS One | Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model Pubmed: 31247004 |
| Frontiers in Immunology | C5a/C5aR Pathway is Critical for the Pathogenesis of Psoriasis Pubmed: 31447855 |
| Phytomedicine | Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 … |
| Aging | C5aR deficiency attenuates the breast cancer development via the p38/p21 axis Pubmed: 32669478 |
| STEM CELL REVIEWS AND REPORTS | A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem … Pubmed: 32406006 |
| Modulation of C5a-C5aR interactions against murine mammary cancer cell line | |
| FASEB J | C‐reactive protein inhibits C3a/C3aR‐dependent podocyte autophagy in favor of diabetic kidney disease Pubmed:35503088 |
| Catalog No. | Related products for research use of Homo sapiens (Human) Organism species | Applications (RESEARCH USE ONLY!) |
| RPA388Hu01 | Recombinant Complement Component 5a (C5a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA388Hu62 | Active Complement Component 5a (C5a) | Cell culture; Activity Assays. |
| APA388Hu61 | Active Complement Component 5a (C5a) | Cell culture; Activity Assays. |
| EPA388Hu61 | Eukaryotic Complement Component 5a (C5a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAA388Hu06 | Polyclonal Antibody to Complement Component 5a (C5a) | WB; IHC; ICC; IP. |
| PAA388Hu01 | Polyclonal Antibody to Complement Component 5a (C5a) | WB; IHC; ICC; IP. |
| MAA388Hu21 | Monoclonal Antibody to Complement Component 5a (C5a) | WB,IHC |
| MAA388Hu22 | Monoclonal Antibody to Complement Component 5a (C5a) | WB; IHC |
| MAA388Hu23 | Monoclonal Antibody to Complement Component 5a (C5a) | WB; IHC; ICC; IP. |
| MAA388Hu24 | Monoclonal Antibody to Complement Component 5a (C5a) | WB; IHC; ICC; IP. |
| SEA388Hu | ELISA Kit for Complement Component 5a (C5a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA388Hu | Magnetic Luminex Assay Kit for Complement Component 5a (C5a) ,etc. | Magnetic Luminex Assay for Antigen Detection. |
| KSA388Hu01 | ELISA Kit DIY Materials for Complement Component 5a (C5a) | Main materials for "Do It (ELISA Kit) Yourself". |
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