Cloud-clone
SKU:RPA971Hu01
Recombinant Glypican 3 (GPC3)
Recombinant Glypican 3 (GPC3)
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Prokaryotic expression
Product No.
RPA971Hu01
Organism Species
Homo sapiens (Human) .
Source
Prokaryotic expression
Host
E.coli
Endotoxin Level
<1.0EU per 1µg (determined by the LAL method)
Subcellular Location
Secreted, Extracellular matrix
Predicted Molecular Mass
54.6kDa
Accurate Molecular Mass
55kDa(Analysis of differences refer to the manual)
Residues & Tags
Thr343~His559 with N-terminal His and GST Tag
Buffer Formulation
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Traits
Freeze-dried powder
Purity
> 95%
Isoelectric Point
6.0
Applications
Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
UOM
10µg 50µg 200µg 1mg 5mg
SEQUENCE
USAGE
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
STORAGE
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
| Magazine | Citations |
| Nature and Science | Diagnostic Role of Serum Glypican-3 as a Tumor Marker for Hepatocellular Carcinoma Sciencepub:10043238 |
| Journal of Applied Pharmaceutical Science | Cytotoxic effects of antiglypican-3 against HepG2 cell line Ebscohost: Source |
| Asian Pacific Journal of Cancer Prevention | Can Glypican3 be Diagnostic for Early Hepatocellular Carcinoma among Egyptian Patients? Pubmed: 24460300 |
| Clin Biochem. | Diagnostic accuracy of serum glypican-3 for hepatocellular carcinoma: A systematic review and meta-analysis Pubmed: 24362268 |
| Science and Nature | Diagnostic Role of Serum Glypican-3 as Hepatocellular Carcinoma Zolcat: Source |
| Alexandria Journal of Medicine | Role of serum glypican-3 in the diagnosis and differentiation of small hepatocellular carcinoma from hepatitis-C virus cirrhosis ScienceDirect: S2090506814000062 |
| J Egypt Natl Canc Inst. | Comparing prothrombin induced by vitamin K absence-II (PIVKA-II) with the oncofetal proteins glypican-3, Alpha feto protein and carcinoembryonic antigen in diagnosing hepatocellular carcinoma among Egyptian patients. Pubmed:24841158 |
| European Journal of Pharmacology | Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma Pubmed:25449037 |
| Hepatobiliary Pancreat Dis Int | Predictive value of tumor markers in patients with recurrent hepatocellular carcinoma in different vascular invasion pattern abstract:abstract4525.shtml |
| Clinical and Molecular Hepatology | Glypican-3 level assessed by the enzyme-linked immunosorbent assay is inferior to alpha-fetoprotein level for hepatocellular carcinoma diagnosis pmc:articles |
| Wiley | Glypican‐3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment pubmed:28621802 |
| Biomedicine & Pharmacotherapy | Cytotoxic and partial hepatoprotective activity of sodium ascorbate against hepatocellular carcinoma through inhibition of sulfatase-2 and Pubmed:29669302 |
| Journal of Cancer and Clinical Oncology | Development and Validation of a Two-Site Immunoradiometric assay for Glypican-3 in plasma: Implication in Diagnosis of Hepatocellular Carcinoma Researchgate:Source |
| Turkish journal of oncology | Serum Glypican-3, Vascular Endothelial Growth Factor, and Interleukin-6 Levels in Hepatocellular Carcinoma 10.5505:tjo.2018.1742 |
| Intensive Care Medicine Experimental | Elevated plasma glypicans are associated with organ failure in patients with infection Pubmed: 30618011 |
| VALUE OF SERUM GLYPICAN 3 AS A PREDICTIVE TOOL FOR EARLY DIAGNOSIS OF HEPATOCELLULAR CARCINOMA (HCC) | |
| ADVANCED RESEARCHES | Search for Effective Serum Tumor Markers for Early Diagnosis of Hepatocellular Carcinoma Associated with Hepatitis C |
| Life Sci | Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and … Pubmed:35640776 |
| Catalog No. | Related products for research use of Homo sapiens (Human) Organism species | Applications (RESEARCH USE ONLY!) |
| RPA971Hu02 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA971Hu01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAA971Hu01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; ICC; IHC-P; IHC-F; ELISA. |
| MAA971Hu21 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| MAA971Hu22 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| MAA971Hu24 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| MAA971Hu23 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| MAA971Hu25 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| SEA971Hu | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA971Hu | Magnetic Luminex Assay Kit for Glypican 3 (GPC3) ,etc. | Magnetic Luminex Assay for Antigen Detection. |
