Cloud-clone
SKU:RPB222Ra01
Recombinant Synuclein Alpha (SNCa)
Recombinant Synuclein Alpha (SNCa)
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Prokaryotic expression
Product No.
RPB222Ra01
Organism Species
Rattus norvegicus (Rat).
Source
Prokaryotic expression
Host
E.coli
Endotoxin Level
<1.0EU per 1µg (determined by the LAL method)
Subcellular Location
Cytoplasm
Predicted Molecular Mass
13.5kDa
Accurate Molecular Mass
13&17kDa(Analysis of differences refer to the manual)
Residues & Tags
Lys23~Ala140 with N-terminal His Tag
Buffer Formulation
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Traits
Freeze-dried powder
Purity
> 97%
Isoelectric Point
5.1
Applications
Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
UOM
10µg 50µg 200µg 1mg 5mg
SEQUENCE
USAGE
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
STORAGE
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
| Magazine | Citations |
| The Journal of Clinical Investigation | Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegeneration PubMed: PMC3428100 |
| Neurobiology of Disease | Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission PubMed: PMC3107939 |
| Nature Communications | Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus PubMed: PMC3265381 |
| Provisional chapter | Mutations of PARK Genes and Alpha-Synuclein and Parkin Concentrations in Parkinson’s Disease Intechopen:Source |
| Nerodegeneration | Apolipoprotein Eε4: A Biomarker for Executive Dysfunction among Parkinson's Disease Patients with Mild Cognitive Impairment pubmed:29326545 |
| Experimental gerontology | The anti-aging protein klotho alleviates injury of nigrostriatal dopaminergic pathway in 6-hydroxydopamine rat model of Parkinson's disease: Involvement of PKA/CaMKII/CREB signaling. pubmed:29107062 |
| Neurobiology of Disease | Development and biochemical characterization of a mouse model of Parkinson's disease bearing defective glucocerebrosidase activity Pubmed: 30521842 |
| molecular and cellular biochemistry | Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson's disease mice model Pubmed: 31820278 |
| International Journal of Pharmacology | Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease Pubmed: 32084576 |
| EBioMedicine | Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys Pubmed: 32810825 |
| Catalog No. | Related products for research use of Rattus norvegicus (Rat) Organism species | Applications (RESEARCH USE ONLY!) |
| RPB222Ra01 | Recombinant Synuclein Alpha (SNCa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAB222Ra01 | Polyclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC; IP. |
| MAB222Ra21 | Monoclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC; IP. |
| SEB222Ra | ELISA Kit for Synuclein Alpha (SNCa) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMB222Ra | Magnetic Luminex Assay Kit for Synuclein Alpha (SNCa) ,etc. | Magnetic Luminex Assay for Antigen Detection. |
| KSB222Ra01 | ELISA Kit DIY Materials for Synuclein Alpha (SNCa) | Main materials for "Do It (ELISA Kit) Yourself". |
