Cloud-clone
SKU:RPC128Hu02
Recombinant Gremlin 1 (GREM1)
Recombinant Gremlin 1 (GREM1)
Couldn't load pickup availability
Prokaryotic expression
Product No.
RPC128Hu02
Organism Species
Homo sapiens (Human).
Source
Prokaryotic expression
Host
E.coli
Endotoxin Level
<1.0EU per 1µg (determined by the LAL method)
Subcellular Location
Secreted
Predicted Molecular Mass
21.9kDa
Accurate Molecular Mass
25kDa(Analysis of differences refer to the manual)
Residues & Tags
Lys26~Asp184 with N-terminal His Tag
Buffer Formulation
PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Traits
Freeze-dried powder
Purity
> 97%
Isoelectric Point
9.6
Applications
Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
UOM
10µg 50µg 200µg 1mg 5mg
SEQUENCE
USAGE
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
STORAGE
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
| Magazine | Citations |
| Lung | Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension PubMed: 25926293 |
| Tumour Biol | Overexpression of Gremlin promotes non-small cell lung cancer progression PubMed: 26392110 |
| Int J Cardiol | Triple head-to-head comparison of fibrotic biomarkers galectin-3, osteopontin and gremlin-1 for long-term prognosis in suspected and proven acute heart failure patients PubMed: 26539964 |
| International Journal of Cardiology | Triple head-to-head comparison of fibrotic biomarkers galectin-3, osteopontin and gremlin-1 for long-termprognosis in suspected and proven acute heart failure patients Pubmed:26539964 |
| American Journal of Respiratory Cell and Molecular Biology | BMPR2 Mutation-independent Mechanisms of Disrupted BMP Signaling in IPAH Pubmed:27187737 |
| J Rheumatol | GREM1 Is a Key ReCavia (Guinea pig )lator of Synoviocyte Hyperplasia and Invasiveness Pubmed:26834210 |
| European cells & materials | The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells. pubmed:28266688 |
| Sci Rep. | Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients. pubmed:28327551 |
| American Journal of Respiratory Cell and Molecular Biology | Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial … rcmb.2015-0402OC |
| Molecular Medicine Reports | Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells pubmed:28260028 |
| Cellular Haemostasis and Platelets | Platelets as a novel source of Gremlin-1: Implications for thrombo inflammation pubmed:27929199 |
| Scientific Reports | Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis Pubmed: 31053735 |
| International Journal of Molecular Sciences | Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration Pubmed: 31878307 |
| American Journal of Physiology-Cell Physiology | Suppression of microRNA-23a/b-3p delays the development degenerative joint disease by activating Grem1 and TGF-β/Smad signaling pathway Pubmed: 32186934 |
| Inflammopharmacology | Protective role of microRNA-23a/b-3p inhibition against osteoarthritis through Gremlin1-depenent activation of TGF-β/smad signaling in chondrocytesa Pubmed:35441352 |
| Mol Carcinog | CAF‐derived exosomes transmitted Gremlin‐1 promotes cancer progression and decreases the sensitivity of hepatoma cells to sorafenib Pubmed:35638711 |
| Catalog No. | Related products for research use of Homo sapiens (Human) Organism species | Applications (RESEARCH USE ONLY!) |
| APC128Hu02 | Active Gremlin 1 (GREM1) | Cell culture; Activity Assays. |
| RPC128Hu01 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APC128Hu01 | Active Gremlin 1 (GREM1) | Cell culture; Activity Assays. |
| RPC128Hu02 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAC128Hu01 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
| PAC128Hu02 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
| LAC128Hu81 | FITC-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IF. |
| LAC128Hu71 | Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC. |
| MAC128Hu21 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
| MAC128Hu23 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
| RAC128Hu21 | Recombinant Antibody to Gremlin 1 (GREM1) | WB; IF; ICC; IHC; IP; FCM. |
| MAC128Hu22 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB,IHC |
| SEC128Hu | ELISA Kit for Gremlin 1 (GREM1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMC128Hu | Magnetic Luminex Assay Kit for Gremlin 1 (GREM1) ,etc. | Magnetic Luminex Assay for Antigen Detection. |
