anti- Acetylated tubulin(Lys40) antibody

Illuminate the intricacies of microtubule dynamics with our Anti-Acetylated Tubulin(Lys40) Antibody. With a generous 100µg supply, this antibody empowers you to explore acetylated tubulin, shedding light on cellular processes such as cytoskeleton organization and intracellular transport.

Microtubules, composed of tubulin subunits, play a pivotal role in maintaining cell shape and facilitating intracellular transport. Acetylation of tubulin at lysine 40 is a post-translational modification associated with stable and long-lived microtubules. Our antibody is meticulously crafted to specifically target acetylated tubulin (Lys40), ensuring precise and sensitive detection.

Utilizing state-of-the-art techniques, this antibody is designed to provide reliable and consistent results. Whether you're conducting immunofluorescence, live cell imaging, or other assays to study microtubule dynamics and its implications in cell biology, this antibody is your reliable research partner.

Investigations into acetylated tubulin are vital for understanding processes like cell division, intracellular transport, and neuronal function. Our Anti-Acetylated Tubulin(Lys40) Antibody can contribute to advancements in these fields by enabling accurate detection and visualization of acetylated microtubules.

Elevate your research with the precision and reliability of our Anti-Acetylated Tubulin(Lys40) Antibody. Secure your 100µg supply today and embark on a journey to uncover the intricacies of microtubule biology.

Product Name

Acetylated tubulin(Lys40) antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin; it does not recognize non-acetylated tubulin.

IMMUNOGEN INFORMATION

Immunogen

tubulin, alpha 1a

Synonyms

Acetylated alpha tubulin, Acetylated tubulin, acetylated-a-tubulin, acetyl-a-tubulin, alpha tubulin, Alpha tubulin 3, tubulin,TUBA1A

Observed MW

52 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:5000; IF: 1:20-1:200; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q71U36

IMAGES

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab00082(Acetylated tubulin(Lys40) Antibody) at dilution of 1:50

L02 cells were subjected to SDS PAGE followed by western blot with FNab00082(Acetylated tubulin(Lys40) Antibody) at dilution of 1:1000