anti- ACK1 antibody

Explore the intricate world of cellular signaling with our Anti-ACK1 Antibody. Available in a generous 100µg size, this antibody empowers you to delve into ACK1 and its pivotal role in regulating diverse signaling pathways.

ACK1, also known as activated Cdc42-associated kinase 1, is a versatile tyrosine kinase that plays a crucial role in various cellular processes, including cell growth, proliferation, and survival. Our antibody is meticulously crafted to specifically target ACK1 with remarkable precision and sensitivity. Thoroughly validated, it ensures consistent and dependable results, instilling confidence in your exploration of signaling mechanisms.

Produced using state-of-the-art techniques, this antibody is sourced from rabbit hosts, offering a polyclonal clonality that enhances its range of binding capabilities. Its versatility makes it an ideal choice for diverse applications, including Western blotting, immunoprecipitation, and immunofluorescence assays.

Whether you're investigating cell signaling pathways, studying kinase regulation, or exploring diseases related to ACK1 dysregulation, our Anti-ACK1 Antibody is your trusted research companion. Its high-quality formulation and generous 100µg size ensure it is an indispensable asset for your laboratory, enabling groundbreaking discoveries and contributions to the field of cellular signaling.

Elevate your research with the precision and reliability of our Anti-ACK1 Antibody. Secure your 100µg supply today and embark on a journey of discovery with confidence.

Product Name

ACK1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. The 60-70kd band is the isoform 2 of TNK2. Isoform 1 and 3 is about 120-125kd.

IMMUNOGEN INFORMATION

Immunogen

tyrosine kinase, non-receptor, 2

Synonyms

TNK2, ACK1, ACK, FLJ45547, ACK 1

Observed MW

70 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q07912

IMAGES

Immunohistochemistry of paraffin-embedded human breast cancer using FNab00086(ACK1 antibody) at dilution of 1:50

SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab00086(ACK1 antibody) at dilution of 1:500