anti- ALPL antibody

Unlock the secrets of tissue-specific alkaline phosphatases with our meticulously crafted Anti-ALPL Polyclonal Antibody, available in a convenient 100µg size. ALPL, or tissue-nonspecific alkaline phosphatase, is a ubiquitous enzyme involved in diverse physiological processes, including bone mineralization and liver function. This high-quality polyclonal antibody offers exceptional specificity and sensitivity, making it an ideal choice for various research applications, from immunohistochemistry to enzyme activity assays.

Our Anti-ALPL Polyclonal Antibody has been rigorously validated and tested to ensure reliable and consistent results, reducing experimental variability and optimizing resource utilization. With 100µg of antibody, this product balances cost-effectiveness and practicality, providing ample material for multiple experiments while minimizing wastage, aligning with sustainable research practices.

Designed for user-friendliness, this antibody suits researchers of all levels, enhancing the precision and reliability of experiments across a range of laboratory techniques. Contribute to a deeper understanding of enzyme biology and its pivotal roles in health and disease with confidence, supported by our high-quality Anti-ALPL Polyclonal Antibody. Drive advancements in enzymology research and be part of groundbreaking discoveries in tissue-specific enzyme regulation.

Product Name

ALPL antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney(tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. ALPL(Alkaline phosphatase, tissue-nonspecific isozyme) is also named as AP-TNAP, TNSALP and belongs to the alkaline phosphatase family. It can exsit as a homodimer with the molecular weight of 140 kDa(PMID:18724009). ALPL was synthesized as a 66-kDa endo-b-N-acetylglucos-aminidase H(Endo H)-sensitive form, and processed to an 80-kDa mature form, which is anchored to the plasma membrane via glycosylphosphatidylinositol(GPI)(PMID:10839996).This antibody can bind the four mentioned alkaline phosphatases.

IMMUNOGEN INFORMATION

Immunogen

alkaline phosphatase, liver/bone/kidney

Synonyms

Alkaline phosphatase, Alkaline phosphatase liver/bone/kidney isozyme, Alkaline phosphatase tissue nonspecific isozyme, ALPL, BLAP, Bone Alkaline Phosphatase, NBAP

Observed MW

60-80 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, FC

Recommended Dilution

WB: 1:500-1:3000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P05186

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