anti- APC antibody

Introducing our Anti-APC Antibody, a powerful and versatile tool meticulously designed to advance your research in the critical field of cell cycle regulation and tumor suppression. APC, or Adenomatous Polyposis Coli, is a tumor suppressor protein crucial for maintaining genomic stability and preventing the uncontrolled cell division that leads to cancer. Our carefully crafted antibody, available in a 100µg size, offers exceptional specificity and sensitivity, ensuring the precision and reliability necessary for your research endeavors.

With 100µg of this high-quality antibody at your disposal, you have the flexibility to conduct a wide range of experiments and assays. Whether you're investigating APC's roles in cell cycle checkpoints, exploring its interactions with other regulatory proteins, or dissecting its implications in cancer pathways, this antibody empowers you with the precision required for impactful scientific discoveries.

Our Anti-APC Antibody has undergone rigorous validation to ensure its reliability and reproducibility. You can trust in the consistency of your results, enabling you to draw accurate conclusions and make significant strides in your research endeavors, particularly in the realm of cancer biology and tumor suppression mechanisms.

APC's pivotal functions in regulating the cell cycle demand an antibody of exceptional quality, and our product is precisely engineered to meet these demands. Whether you are an experienced cancer researcher or just beginning your scientific journey, our Anti-APC Antibody promises to be an invaluable asset in your laboratory. Trust in its quality to drive your scientific discoveries forward, one experiment at a time, as you uncover the intricacies of cell cycle control and tumor suppression mechanisms.

Product Name

APC antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor(HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

IMMUNOGEN INFORMATION

Immunogen

adenomatous polyposis coli

Synonyms

adenomatous polyposis coli, APC, BTPS2, Deleted in polyposis 2.5, DP2, DP2.5, DP3, GS, Protein APC

Observed MW

300 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P25054

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