anti- APP(C-Terminal)antibody

Unravel the complexities of Alzheimer's disease and neuronal biology with our Anti-APP (C-Terminal) Antibody, available in a convenient 100µg size. Amyloid Precursor Protein (APP), a transmembrane protein, plays a central role in the pathogenesis of Alzheimer's disease.

This antibody is meticulously designed to target the C-terminal region of APP, ensuring exceptional specificity and sensitivity for accurate and reproducible results in various applications, from Western blotting to immunohistochemistry. Whether you're investigating APP processing or its implications in neurodegeneration, our antibody is your trusted research companion.

The 100µg size offers cost-effective flexibility, accommodating both small-scale experiments and larger research initiatives. Its consistent quality and purity make it an ideal choice for researchers across diverse disciplines, from neuroscience to molecular biology.

Choose our Anti-APP (C-Terminal) Antibody to propel your research forward and gain fresh insights into APP-related processes. Rely on its performance and join the community of scientists who trust our products to drive scientific discovery.

Product Name

APP antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

IMMUNOGEN INFORMATION

Immunogen

amyloid beta A4 precursor protein

Synonyms

A4, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Beta-amyloid precursor protein,
CVAP, PreA4

Observed MW

110 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

P05067

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