anti- APP antibody

Delve into the intricate world of neurodegenerative diseases and cellular biology with our Anti-APP Antibody, available in a convenient 100µg size. Amyloid Precursor Protein (APP) is a transmembrane protein involved in the formation of amyloid plaques in Alzheimer's disease.

This antibody is expertly crafted for exceptional specificity and sensitivity, ensuring reliable and reproducible results in various applications, from Western blotting to immunohistochemistry. Whether you're exploring APP's functions in synaptic plasticity or its implications in neuroprotection, our antibody is your dependable research partner.

The 100µg size provides cost-effective versatility, catering to both small-scale experiments and larger research projects. Its consistent quality and purity make it an ideal choice for researchers across diverse disciplines, from neurobiology to drug discovery.

Choose our Anti-APP Antibody to propel your research forward and gain deeper insights into APP-related processes. Count on its performance and join the ranks of scientists who rely on our products to advance scientific understanding.

Product Name

APP antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.

IMMUNOGEN INFORMATION

Immunogen

amyloid beta A4 precursor protein

Synonyms

A4, ABPP,Alzheimer disease amyloid protein,Cerebral vascular amyloid peptide,Beta-amyloid precursor protein,
CVAP,PreA4

Observed MW

100 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P05067

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