anti- ARHGEF18 antibody

Uncover the intricacies of Rho guanine nucleotide exchange factors (ARHGEFs) with our Anti-ARHGEF18 Antibody, available in a convenient 100µg size. ARHGEF18, also known as Asef2, is a critical regulator of Rho family GTPases, playing a pivotal role in cytoskeletal dynamics, cell migration, and intracellular signaling.

This highly specific antibody offers exceptional sensitivity and specificity, ensuring accurate and reproducible results in various applications, from Western blotting to immunocytochemistry. Whether you're investigating ARHGEF18's functions in cell adhesion, its role in neuronal development, or its implications in cancer progression, our antibody is your trusted research partner.

The 100µg size provides cost-effective flexibility, accommodating both small-scale experiments and larger research initiatives. Its consistent quality and purity make it an ideal choice for researchers across diverse disciplines, from cell biology to cancer research.

Choose our Anti-ARHGEF18 Antibody to advance your research and gain deeper insights into the complex world of Rho GTPase regulation. Count on its performance, specificity, and reliability to drive your scientific discovery forward and contribute to the body of knowledge in your field.

Product Name

ARHGEF18 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).

IMMUNOGEN INFORMATION

Immunogen

rho/rac guanine nucleotide exchange factor(GEF) 18

Synonyms

KIAA0521

Observed MW

120-130 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q6ZSZ5

IMAGES