anti- ARHGEF4 antibody

Delve into the intricate world of Rho guanine nucleotide exchange factors (ARHGEFs) with our Anti-ARHGEF4 Antibody, available in a convenient 100µg size. ARHGEF4, also known as p115-RhoGEF, is a critical regulator of Rho family GTPases, influencing cytoskeletal dynamics, cell migration, and adhesion.

This highly specific antibody offers exceptional sensitivity and specificity, ensuring accurate and reproducible results in various applications, from Western blotting to immunohistochemistry. Whether you're investigating ARHGEF4's role in cell motility, its implications in tissue development, or its involvement in cancer biology, our antibody is your dependable research ally.

The 100µg size provides cost-effective versatility, catering to both small-scale experiments and larger research initiatives. Its consistent quality and purity make it a reliable choice for researchers across diverse disciplines, from cell biology to developmental biology.

Choose our Anti-ARHGEF4 Antibody to propel your research forward and gain fresh insights into the complex world of Rho GTPase regulation. Rely on its performance, specificity, and reliability to drive your scientific discovery and contribute to the body of knowledge in your field.

Product Name

ARHGEF4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Acts as guanine nucleotide exchange factor(GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

IMMUNOGEN INFORMATION

Immunogen

Rho guanine nucleotide exchange factor(GEF) 4

Synonyms

KIAA1112

Observed MW

72 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NR80

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