anti- Ataxin 2 antibody

Investigate the role of Ataxin 2 in neurodegenerative disorders with our Anti-Ataxin 2 Antibody, now available in a convenient 100µg size. Ataxin 2, a key protein involved in RNA metabolism and stress granule dynamics, is gaining recognition for its implications in various neurological conditions.

Our meticulously developed monoclonal antibody ensures unparalleled specificity and sensitivity. Whether you're conducting Western blotting, immunoprecipitation, or immunofluorescence, trust in our antibody to deliver consistent and reliable results.

The 100µg size provides an ample supply for your experiments, minimizing interruptions and allowing you to maintain the momentum of your research.

Don't miss the opportunity to contribute to the understanding of neurodegenerative disorders. With our Anti-Ataxin 2 Antibody, you can confidently delve into your research and uncover the connections between Ataxin 2 and neurological health.

Product Name

Ataxin 2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.

IMMUNOGEN INFORMATION

Immunogen

ataxin 2

Synonyms

ataxin 2, ATX2, ATXN2, SCA2, TNRC13

Observed MW

140-150 kDa

APPLICATION

Tested Application

ELISA, IHC, IF, WB, IP

Recommended Dilution

WB: 1:1000-1:4000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q99700

IMAGES