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Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab00664(ATF6 Antibody) at dilution of 1:50 -
Immunofluorescent analysis of HeLa cells using FNab00664 (ATF6 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG -
IP Result of anti-ATF6 (IP:FNab00664, 4ug; Detection:FNab00664 1:1500) with HeLa cells lysate 2800ug. -
MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab00664(ATF6 Antibody) at dilution of 1:3000
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SKU:FNab00664
anti- ATF6 antibody
anti- ATF6 antibody
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$290.00 USD
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$290.00 USD
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Navigate the complex world of endoplasmic reticulum (ER) stress responses with our Anti-ATF6 Antibody, now available in a 100µg size. ATF6, a crucial transcription factor, is a central player in the unfolded protein response (UPR), a cellular pathway essential for ER homeostasis.
This antibody, meticulously developed for specificity and sensitivity, is suitable for various experimental applications, including Western blotting, immunoprecipitation, and immunofluorescence.
With 100µg at your disposal, you have an ample supply for multiple experiments, reducing interruptions and allowing you to maintain the momentum of your research.
Uncover the intricacies of ER stress responses with our Anti-ATF6 Antibody. Trust in its precision and reliability to guide your research toward groundbreaking discoveries in the field of cellular stress and protein folding.
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Product Name
ATF6 antibody
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BACKGROUND
Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response(UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element(ERSE)(5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II(5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
IMMUNOGEN INFORMATION
Immunogen
activating transcription factor 6
Synonyms
ATF6, ATF6 alpha, ATF6A
Observed MW
90 kDa
APPLICATION
Tested Application
ELISA, WB, IF, IHC, IP
Recommended Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
UNIPROT INFORMATION
UniProt ID
IMAGES
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