anti- ATG12 antibody

Illuminate the process of autophagy conjugation with our Anti-ATG12 Polyclonal Antibody, available in a 100µg size. ATG12, a critical component of the autophagy machinery, is involved in the conjugation system crucial for autophagosome formation and cargo engulfment.

Derived from rabbit hosts, this polyclonal antibody offers exceptional sensitivity and versatility for a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its polyclonal nature allows for recognition of multiple epitopes, enhancing its utility in diverse research contexts.

With 100µg at your disposal, you have a generous supply for multiple experiments, reducing the need for frequent reordering and ensuring the continuity of your research.

Don't miss the opportunity to unravel the intricacies of autophagy conjugation with our Anti-ATG12 Polyclonal Antibody. Trust in its precision and reliability to guide your research toward groundbreaking discoveries in cellular quality control and recycling processes.

Product Name

ATG12 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

IMMUNOGEN INFORMATION

Immunogen

ATG12 autophagy related 12 homolog

Synonyms

APG12, APG12L

Observed MW

48-50kd

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

O94817

IMAGES