anti- ATG4D antibody

Explore the role of ATG4D in autophagy with our Anti-ATG4D Antibody, available in a 100µg size. ATG4D, a critical autophagy-related protein, plays a pivotal role in the processing and maturation of autophagosomes, essential for cellular quality control and the removal of damaged components.

Our meticulously developed monoclonal antibody ensures unparalleled specificity and sensitivity, making it the ideal choice for a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. It provides the precision and reliability needed for accurate results in your autophagy research.

With 100µg at your disposal, you have an ample supply for multiple experiments, minimizing interruptions and allowing you to maintain the momentum of your research.

Don't miss the opportunity to shed light on the multifaceted functions of ATG4D in autophagy. With our Anti-ATG4D Antibody, you can confidently delve into your research and uncover the secrets hidden within this essential autophagy-related protein.

Product Name

ATG4D antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport(Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine(PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.

IMMUNOGEN INFORMATION

Immunogen

ATG4 autophagy related 4 homolog D

Synonyms

APG4 D, APG4D, ATG4D, AUTL4, Autophagin 4, Cysteine protease ATG4D

Observed MW

53 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:1000

UNIPROT INFORMATION

UniProt ID

Q86TL0

IMAGES

mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab00676(ATG4D antibody) at dilution of 1:500