anti- ATG5 antibody

Illuminate the intricate pathways of autophagy with our Anti-ATG5 Antibody, now available in a 100µg size. ATG5, a critical autophagy-related protein, is essential for autophagosome formation and the conjugation of proteins necessary for cellular quality control and the removal of damaged components.

Our meticulously developed monoclonal antibody ensures unparalleled specificity and sensitivity, making it the ideal choice for a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. It provides the precision and reliability needed for accurate results in your autophagy research.

With 100µg at your disposal, you have an ample supply for multiple experiments, reducing interruptions and allowing you to maintain the momentum of your research.

Don't miss the opportunity to unravel the mysteries of autophagy and the essential role of ATG5. With our Anti-ATG5 Antibody, you can confidently delve into your research and uncover the secrets hidden within this critical autophagy-related protein.

Product Name

ATG5 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.

IMMUNOGEN INFORMATION

Immunogen

ATG5 autophagy related 5 homolog

Synonyms

APG5L, ASP

Observed MW

50-55 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:1000-1:3000

UNIPROT INFORMATION

UniProt ID

Q9H1Y0

IMAGES