anti- ATR antibody

Illuminate your research on DNA damage signaling with our Anti-ATR Antibody. This 100µg antibody is your passport to uncovering the role of ATR, a critical protein in the cellular response to DNA damage.

Engineered for precision and reliability, this antibody excels in a range of applications, from Western blotting to immunohistochemistry. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, empowering you to advance your research with confidence.

ATR plays a pivotal role in activating the DNA damage response pathway, making it an essential component of genome maintenance. With this antibody in your arsenal, you're better equipped to explore its functions. Whether you're investigating cell cycle checkpoints or studying diseases related to ATR, this antibody is your trusted research partner.

Elevate your scientific endeavors by ordering your Anti-ATR Antibody today and take a significant step forward in your research journey.

Product Name

ATR antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation(IR), ultraviolet light(UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

IMMUNOGEN INFORMATION

Immunogen

ataxia telangiectasia and Rad3 related

Synonyms

ATR, FRAP related protein 1, FRP1, MEC1, SCKL, SCKL1

Observed MW

250-290kd

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:300-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q13535

IMAGES