anti- AXIN1 antibody

Decipher the intricate mechanisms of Wnt signaling with our Anti-AXIN1 Antibody. This 100µg antibody is your key to unraveling the role of AXIN1, a critical component in the Wnt pathway.

Engineered for accuracy and reliability, this antibody excels in a range of applications, from Western blotting to immunohistochemistry. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, making it an indispensable tool in your laboratory.

AXIN1 is a key player in the regulation of Wnt signaling, crucial for developmental processes and cancer biology. With this antibody in your toolkit, you're better equipped to explore its functions. Whether you're investigating tissue homeostasis or studying diseases related to AXIN1 dysregulation, this antibody is your trusted research partner.

Invest in scientific excellence by ordering your Anti-AXIN1 Antibody today and embark on a journey towards a deeper understanding of Wnt signaling.

Product Name

AXIN1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

IMMUNOGEN INFORMATION

Immunogen

axin 1

Synonyms

AXIN, axin 1, AXIN1, Axis inhibition protein 1, hAxin

Observed MW

100-110kd

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

O15169

IMAGES