anti- AXL antibody

Illuminate your research on the AXL receptor with our Anti-AXL Antibody. This 100µg antibody is your key to uncovering the functions of AXL, a receptor tyrosine kinase associated with cancer and immune regulation.

Engineered for precision and reliability, this antibody excels in a range of applications, from Western blotting to immunohistochemistry. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, allowing you to advance your research with confidence.

AXL is a pivotal player in cell signaling and is implicated in cancer progression and immune evasion. With this antibody in your toolkit, you're better equipped to explore its functions. Whether you're investigating oncogenic pathways or studying the immune response, this antibody is your trusted research partner.

Elevate your scientific endeavors by ordering your Anti-AXL Antibody today and gain deeper insights into the dynamic world of the AXL receptor.

Product Name

AXL antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors(TLRs)-mediated innate immune response. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:17005688).

IMMUNOGEN INFORMATION

Immunogen

AXL receptor tyrosine kinase

Synonyms

AXL, AXL oncogene, AXL receptor tyrosine kinase, JTK11, UFO

Observed MW

140 kDa

APPLICATION

Tested Application

ELISA, WB, IP, FC

Recommended Dilution

WB: 1:500-1:3000; IP: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

P30530

IMAGES