anti- BAP1 antibody

Unveil the functions of BAP1 with our Anti-BAP1 Antibody. This 100µg antibody is your key to deciphering the roles of BAP1, a deubiquitinating enzyme involved in chromatin remodeling and tumor suppression.

Engineered for accuracy and reliability, this antibody excels in a range of applications, from Western blotting to chromatin immunoprecipitation. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, allowing you to advance your research with confidence.

BAP1 is a central player in epigenetic regulation and has implications in cancer research and developmental biology. With this antibody in your arsenal, you're better equipped to explore its functions. Whether you're investigating chromatin modification pathways or studying the molecular basis of cancer, this antibody is your trusted research partner.

Invest in scientific excellence by ordering your Anti-BAP1 Antibody today and embark on a journey towards a deeper understanding of BAP1 biology.

Product Name

BAP1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119'(H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal(NLS), thereby protecting it from cytoplasmic sequestration(PubMed:24703950). Acts as a tumor suppressor.

IMMUNOGEN INFORMATION

Immunogen

BRCA1 associated protein-1(ubiquitin carboxy-terminal hydrolase)

Synonyms

BAP1, BRCA1 associated protein 1, Cerebral protein 6, HUCEP 13, hucep 6, KIAA0272, UCHL2

Observed MW

91 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:1000

UNIPROT INFORMATION

UniProt ID

Q92560

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