anti- BBS2 antibody

Unveil the functions of BBS2 with our Anti-BBS2 Antibody. This 100µg antibody is your passport to exploring the roles of BBS2, a protein associated with Bardet-Biedl Syndrome (BBS) and ciliopathies.

Engineered for precision and reliability, this antibody excels in various applications, from Western blotting to immunoprecipitation. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, allowing you to advance your research with confidence.

BBS2, a critical component of the BBSome complex, is involved in ciliary biology and intracellular trafficking. With this antibody in your arsenal, you're better equipped to explore its functions. Whether you're investigating cilia-related diseases or studying its role in protein sorting, this antibody is your trusted research companion.

Elevate your scientific endeavors by ordering your Anti-BBS2 Antibody today and gain deeper insights into the dynamic world of BBS2 biology.

Product Name

BBS2 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

IMMUNOGEN INFORMATION

Immunogen

Bardet-Biedl syndrome 2

Observed MW

80 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:500-1:2000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9BXC9

IMAGES