anti- BBS4 antibody

Shed light on the functions of BBS4 with our Anti-BBS4 Antibody. This 100µg antibody is your key to uncovering the roles of BBS4, a protein associated with Bardet-Biedl Syndrome (BBS) and ciliopathies.

Engineered for precision and reliability, this antibody excels in various applications, from Western blotting to immunofluorescence. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, making it an invaluable tool in your research.

BBS4, a component of the BBSome complex, plays a crucial role in cilia biology and ciliary transport processes. With this antibody in your research arsenal, you're better equipped to explore its functions. Whether you're investigating cilia-related disorders or studying its involvement in intracellular trafficking, this antibody is your trusted research companion.

Illuminate the path to scientific discovery by ordering your Anti-BBS4 Antibody today and gain deeper insights into the dynamic world of BBS4 biology.

Product Name

BBS4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.

IMMUNOGEN INFORMATION

Immunogen

Bardet-Biedl syndrome 4

Observed MW

50-60 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q96RK4

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