anti- BBS5 antibody

Unravel the functions of BBS5 with our Anti-BBS5 Antibody. This 100µg antibody is your tool for deciphering the roles of BBS5, a protein involved in ciliary biology and potential implications in ciliopathies.

Engineered for accuracy and reliability, this antibody excels in a range of applications, from Western blotting to immunohistochemistry. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, making it an invaluable addition to your research.

BBS5, also known as Bardet-Biedl Syndrome 5, is a versatile protein with potential implications in cilia biology and ciliopathies. With this antibody in your toolkit, you're better equipped to explore its functions. Whether you're investigating cilia formation mechanisms or studying genetic disorders like Bardet-Biedl syndrome, this antibody is your trusted research companion.

Elevate your scientific endeavors by ordering your Anti-BBS5 Antibody today and gain deeper insights into the dynamic world of BBS5 biology.

Product Name

BBS5 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

IMMUNOGEN INFORMATION

Immunogen

Bardet-Biedl syndrome 5

Observed MW

40-45 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC, IP

Recommended Dilution

WB: 1:1000-1:6000; IP: 1:500-1:3000; IHC: 1:50-1:500; IF: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q8N3I7

IMAGES