anti- BCL2L1 antibody

Delve into the functions of BCL2L1 in apoptosis regulation with our Anti-BCL2L1 Antibody. This 100µg antibody is your gateway to exploring the roles of BCL2L1, a critical protein involved in the control of programmed cell death.

Engineered for precision and reliability, this antibody excels in various applications, from immunoprecipitation to immunohistochemistry. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, making it an indispensable tool in your research.

BCL2L1, also known as BCL-xL, is central to the apoptotic pathway and has implications in cancer research and therapeutic development. With this antibody in your arsenal, you're better equipped to investigate its functions. Whether you're studying cell survival or its role in cancer progression, this antibody is your trusted research companion.

Illuminate the path to scientific discovery by ordering your Anti-BCL2L1 Antibody today and gain deeper insights into the dynamic world of BCL2L1 biology.

Product Name

BCL2L1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis.

IMMUNOGEN INFORMATION

Immunogen

BCL2-like 1

Synonyms

BCL2L, BCLX

Observed MW

35 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:2000-1:20000; IHC: 1:200-1:600; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q07817

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